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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Glutamate receptor ionotropic, NMDA 2B | ||
| Ligand | BDBM50220714 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_449356 (CHEMBL899623) | ||
| IC50 | 10±n/a nM | ||
| Citation |  Kawai, M; Nakamura, H; Sakurada, I; Shimokawa, H; Tanaka, H; Matsumizu, M; Ando, K; Hattori, K; Ohta, A; Nukui, S; Omura, A; Kawamura, M Discovery of novel and orally active NR2B-selective N-methyl-D-aspartate (NMDA) antagonists, pyridinol derivatives with reduced HERG binding affinity. Bioorg Med Chem Lett17:5533-6 (2007) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Glutamate receptor ionotropic, NMDA 2B | |||
| Name: | Glutamate receptor ionotropic, NMDA 2B | ||
| Synonyms: | GluN2B | Glutamate [NMDA] receptor subunit epsilon 2 | Grin2b | N-methyl D-aspartate receptor subtype 2B | NMDA receptor subunit N2B (GluN2B) | NMDAR2B | NMDE2_RAT | NR2B | ||
| Type: | Protein | ||
| Mol. Mass.: | 166077.66 | ||
| Organism: | Rattus norvegicus (Rat) | ||
| Description: | Q00960 | ||
| Residue: | 1482 | ||
| Sequence: |
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| BDBM50220714 | |||
| n/a | |||
| Name | BDBM50220714 | ||
| Synonyms: | CHEMBL237751 | N-((1s,4s)-4-hydroxy-4-(5-hydroxypyridin-2-yl)cyclohexyl)-3-phenylpropanamide | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H24N2O3 | ||
| Mol. Mass. | 340.4162 | ||
| SMILES | Oc1ccc(nc1)[C@@]1(O)CC[C@@H](CC1)NC(=O)CCc1ccccc1 |wD:7.8,11.15,(-10.78,-55,;-9.45,-54.23,;-9.45,-52.68,;-8.13,-51.91,;-6.79,-52.68,;-6.78,-54.21,;-8.1,-54.99,;-5.45,-51.91,;-5.46,-53.44,;-5.45,-50.37,;-4.13,-49.58,;-2.79,-50.37,;-2.79,-51.91,;-4.13,-52.68,;-1.45,-49.6,;-.12,-50.37,;-.12,-51.91,;1.23,-49.61,;2.55,-50.39,;3.89,-49.63,;5.21,-50.4,;6.55,-49.65,;6.56,-48.11,;5.24,-47.33,;3.9,-48.09,)| | ||
| Structure | 
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