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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Glutamate receptor ionotropic, NMDA 2B | ||
| Ligand | BDBM50220727 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_449356 (CHEMBL899623) | ||
| IC50 | 59±n/a nM | ||
| Citation |  Kawai, M; Nakamura, H; Sakurada, I; Shimokawa, H; Tanaka, H; Matsumizu, M; Ando, K; Hattori, K; Ohta, A; Nukui, S; Omura, A; Kawamura, M Discovery of novel and orally active NR2B-selective N-methyl-D-aspartate (NMDA) antagonists, pyridinol derivatives with reduced HERG binding affinity. Bioorg Med Chem Lett17:5533-6 (2007) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Glutamate receptor ionotropic, NMDA 2B | |||
| Name: | Glutamate receptor ionotropic, NMDA 2B | ||
| Synonyms: | GluN2B | Glutamate [NMDA] receptor subunit epsilon 2 | Grin2b | N-methyl D-aspartate receptor subtype 2B | NMDA receptor subunit N2B (GluN2B) | NMDAR2B | NMDE2_RAT | NR2B | ||
| Type: | Protein | ||
| Mol. Mass.: | 166077.66 | ||
| Organism: | Rattus norvegicus (Rat) | ||
| Description: | Q00960 | ||
| Residue: | 1482 | ||
| Sequence: |
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| BDBM50220727 | |||
| n/a | |||
| Name | BDBM50220727 | ||
| Synonyms: | CHEMBL237534 | N-((1r,4r)-4-(3-fluoro-4-hydroxyphenyl)cyclohexyl)-3-phenylpropanamide | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H24FNO2 | ||
| Mol. Mass. | 341.4192 | ||
| SMILES | Oc1ccc(cc1F)[C@H]1CC[C@@H](CC1)NC(=O)CCc1ccccc1 |wU:8.8,wD:11.15,(31.75,-43.6,;33.08,-42.83,;34.43,-43.59,;35.75,-42.81,;35.74,-41.28,;34.4,-40.51,;33.08,-41.28,;31.74,-40.51,;37.08,-40.5,;37.08,-38.96,;38.4,-38.18,;39.74,-38.96,;39.74,-40.5,;38.4,-41.27,;41.08,-38.2,;42.41,-38.97,;42.41,-40.51,;43.76,-38.21,;45.08,-38.99,;46.42,-38.23,;47.74,-39,;49.08,-38.25,;49.09,-36.7,;47.77,-35.93,;46.43,-36.69,)| | ||
| Structure | 
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