Reaction Details |
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Target | Tyrosine-protein phosphatase non-receptor type 1 |
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Ligand | BDBM50228026 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_461676 (CHEMBL927697) |
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IC50 | 160±n/a nM |
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Citation | Douty, B; Wayland, B; Ala, PJ; Bower, MJ; Pruitt, J; Bostrom, L; Wei, M; Klabe, R; Gonneville, L; Wynn, R; Burn, TC; Liu, PC; Combs, AP; Yue, EW Isothiazolidinone inhibitors of PTP1B containing imidazoles and imidazolines. Bioorg Med Chem Lett18:66-71 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein phosphatase non-receptor type 1 |
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Name: | Tyrosine-protein phosphatase non-receptor type 1 |
Synonyms: | PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B) |
Type: | Protein phosphatase |
Mol. Mass.: | 49963.76 |
Organism: | Homo sapiens (Human) |
Description: | Human recombinant GST-fusion PTP1B (1-435). |
Residue: | 435 |
Sequence: | MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH
QEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLK
CAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWP
DFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKD
PSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLE
PPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYG
IESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLT
AGAYLCYRFLFNSNT
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BDBM50228026 |
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n/a |
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Name | BDBM50228026 |
Synonyms: | 2-[4-(2-{1-(3-fluoro-benzenesulfonylamino)-2-[3-methyl-4-(1,1,3-trioxo-1lambda6-isothiazolidin-5-yl)-phenyl]-ethyl}-3H-imidazol-4-yl)-butoxy]-6-hydroxy-benzoic acid methyl ester | CHEMBL274743 |
Type | Small organic molecule |
Emp. Form. | C33H35FN4O9S2 |
Mol. Mass. | 714.781 |
SMILES | COC(=O)c1c(O)cccc1OCCCCc1cnc([nH]1)C(Cc1ccc(C2CC(=O)NS2(=O)=O)c(C)c1)NS(=O)(=O)c1cccc(F)c1 |w:21.41| |
Structure |
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