| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 14 |
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| Ligand | BDBM50243124 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_491669 (CHEMBL946387) |
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| IC50 | 1730±n/a nM |
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| Citation |  Chen, N; Bürli, RW; Neira, S; Hungate, R; Zhang, D; Yu, V; Nguyen, Y; Tudor, Y; Plant, M; Flynn, S; Meagher, KL; Lee, MR; Zhang, X; Itano, A; Schrag, M; Xu, Y; Ng, GY; Hu, E Discovery of a potent and selective c-Kit inhibitor for the treatment of inflammatory diseases. Bioorg Med Chem Lett18:4137-41 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 14 |
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| Name: | Mitogen-activated protein kinase 14 |
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| Synonyms: | CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 41286.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16539 |
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| Residue: | 360 |
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| Sequence: | MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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| BDBM50243124 |
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| n/a |
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| Name | BDBM50243124 |
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| Synonyms: | CHEMBL487863 | N3-(2-acetamidopyrimidin-5-yl)-4-methyl-N1-(3-(trifluoromethyl)phenyl)isophthalamide |
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| Type | Small organic molecule |
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| Emp. Form. | C22H18F3N5O3 |
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| Mol. Mass. | 457.4052 |
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| SMILES | CC(=O)Nc1ncc(NC(=O)c2cc(ccc2C)C(=O)Nc2cccc(c2)C(F)(F)F)cn1 |
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| Structure | 
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