| Reaction Details |
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 | Report a problem with these data |
| Target | Coagulation factor X |
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| Ligand | BDBM50262346 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_509609 (CHEMBL1001370) |
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| IC50 | 462±n/a nM |
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| Citation |  O'Connor, SP; Atwal, K; Li, C; Liu, EC; Seiler, SM; Shi, M; Shi, Y; Stein, PD; Wang, Y Synthesis and evaluation of acylguanidine FXa inhibitors. Bioorg Med Chem Lett18:4696-9 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Coagulation factor X |
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| Name: | Coagulation factor X |
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| Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
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| Type: | Enzyme |
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| Mol. Mass.: | 54726.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 488 |
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| Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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| BDBM50262346 |
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| n/a |
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| Name | BDBM50262346 |
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| Synonyms: | (S)-N-((m-toluidino)(2-oxo-1-(2-oxo-2-(pyrrolidin-1-yl)ethyl)azepan-3-ylamino)methylene)-2,4-dimethylthiazole-5-carboxamide | CHEMBL467144 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H34N6O3S |
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| Mol. Mass. | 510.652 |
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| SMILES | Cc1nc(C)c(s1)C(=O)NC(Nc1cccc(C)c1)=N[C@H]1CCCCN(CC(=O)N2CCCC2)C1=O |r,w:10.11| |
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| Structure | 
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