| Reaction Details |
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 | Report a problem with these data |
| Target | Melanocortin receptor 3 |
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| Ligand | BDBM50253661 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_538610 (CHEMBL1027400) |
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| EC50 | 148±n/a nM |
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| Citation |  Tian, X; Switzer, AG; Derose, SA; Mishra, RK; Solinsky, MG; Mumin, RN; Ebetino, FH; Jayasinghe, LR; Webster, ME; Colson, AO; Crossdoersen, D; Pinney, BB; Farmer, JA; Dowty, ME; Obringer, CM; Cruze, CA; Burklow, ML; Suchanek, PM; Dong, L; Dirr, MK; Sheldon, RJ; Wos, JA Discovery of orally bioavailable 1,3,4-trisubstituted 2-oxopiperazine-based melanocortin-4 receptor agonists as potential antiobesity agents. J Med Chem51:6055-66 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Melanocortin receptor 3 |
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| Name: | Melanocortin receptor 3 |
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| Synonyms: | MC3-R | MC3R | MC3R_HUMAN | Melanocortin MC3 | Melanocortin receptor (M3 and M4) |
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| Type: | Enzyme |
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| Mol. Mass.: | 36044.86 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P41968 |
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| Residue: | 323 |
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| Sequence: | MNASCCLPSVQPTLPNGSEHLQAPFFSNQSSSAFCEQVFIKPEVFLSLGIVSLLENILVI
LAVVRNGNLHSPMYFFLCSLAVADMLVSVSNALETIMIAIVHSDYLTFEDQFIQHMDNIF
DSMICISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALTLIVAIWVCCGVCGVVFI
VYSESKMVIVCLITMFFAMMLLMGTLYVHMFLFARLHVKRIAALPPADGVAPQQHSCMKG
AVTITILLGVFIFCWAPFFLHLVLIITCPTNPYCICYTAHFNTYLVLIMCNSVIDPLIYA
FRSLELRNTFREILCGCNGMNLG
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| BDBM50253661 |
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| n/a |
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| Name | BDBM50253661 |
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| Synonyms: | (S)-2-((S)-3-allyl-4-((R)-2-amino-3-(4-fluorophenyl)propanoyl)-2-oxopiperazin-1-yl)-N-methyl-3-(naphthalen-2-yl)propanamide | CHEMBL462044 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H33FN4O3 |
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| Mol. Mass. | 516.6064 |
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| SMILES | CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN([C@@H](CC=C)C1=O)C(=O)[C@H](N)Cc1ccc(F)cc1 |r| |
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| Structure | 
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