| Reaction Details |
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 | Report a problem with these data |
| Target | Suppressor of tumorigenicity 14 protein |
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| Ligand | BDBM50254024 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_559006 (CHEMBL1010203) |
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| Ki | 145±n/a nM |
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| Citation |  Steinmetzer, T; Dönnecke, D; Korsonewski, M; Neuwirth, C; Steinmetzer, P; Schulze, A; Saupe, SM; Schweinitz, A Modification of the N-terminal sulfonyl residue in 3-amidinophenylalanine-based matriptase inhibitors. Bioorg Med Chem Lett19:67-73 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Suppressor of tumorigenicity 14 protein |
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| Name: | Suppressor of tumorigenicity 14 protein |
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| Synonyms: | Epithin | Hepatocyte growth factor activator/Serine protease hepsin/Suppressor of tumorigenicity 14 protein | MT-SP1 | Membrane-type serine protease 1 | PRSS14 | Prostamin | SNC19 | ST14 | ST14_HUMAN | Serine protease TADG-15 | Suppressor of tumorigenicity 14 protein | Suppressor of tumorigenicity protein 14 | TADG15 |
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| Type: | Single-pass type II membrane protein |
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| Mol. Mass.: | 94769.23 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9Y5Y6 |
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| Residue: | 855 |
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| Sequence: | MGSDRARKGGGGPKDFGAGLKYNSRHEKVNGLEEGVEFLPVNNVKKVEKHGPGRWVVLAA
VLIGLLLVLLGIGFLVWHLQYRDVRVQKVFNGYMRITNENFVDAYENSNSTEFVSLASKV
KDALKLLYSGVPFLGPYHKESAVTAFSEGSVIAYYWSEFSIPQHLVEEAERVMAEERVVM
LPPRARSLKSFVVTSVVAFPTDSKTVQRTQDNSCSFGLHARGVELMRFTTPGFPDSPYPA
HARCQWALRGDADSVLSLTFRSFDLASCDERGSDLVTVYNTLSPMEPHALVQLCGTYPPS
YNLTFHSSQNVLLITLITNTERRHPGFEATFFQLPRMSSCGGRLRKAQGTFNSPYYPGHY
PPNIDCTWNIEVPNNQHVKVRFKFFYLLEPGVPAGTCPKDYVEINGEKYCGERSQFVVTS
NSNKITVRFHSDQSYTDTGFLAEYLSYDSSDPCPGQFTCRTGRCIRKELRCDGWADCTDH
SDELNCSCDAGHQFTCKNKFCKPLFWVCDSVNDCGDNSDEQGCSCPAQTFRCSNGKCLSK
SQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEK
DCDCGLRSFTRQARVVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLVSAAHCYID
DRGFRYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDIALLELEKP
AEYSSMVRPICLPDASHVFPAGKAIWVTGWGHTQYGGTGALILQKGEIRVINQTTCENLL
PQQITPRMMCVGFLSGGVDSCQGDSGGPLSSVEADGRIFQAGVVSWGDGCAQRNKPGVYT
RLPLFRDWIKENTGV
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| BDBM50254024 |
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| n/a |
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| Name | BDBM50254024 |
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| Synonyms: | (+/-)-4'-Methoxy-biphenyl-3-sulfonic acid [2-[4-(2-amino-ethyl)-piperidin-1-yl]-1-(3-aminomethyl-benzyl)-2-oxo-ethyl]-amide | CHEMBL466585 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H38N4O4S |
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| Mol. Mass. | 550.712 |
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| SMILES | COc1ccc(cc1)-c1cccc(c1)S(=O)(=O)NC(Cc1cccc(CN)c1)C(=O)N1CCC(CCN)CC1 |
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| Structure | 
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