| Reaction Details |
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 | Report a problem with these data |
| Target | Vasopressin V2 receptor |
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| Ligand | BDBM50246721 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_560999 (CHEMBL1015239) |
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| EC50 | 120±n/a nM |
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| Citation |  Yea, CM; Allan, CE; Ashworth, DM; Barnett, J; Baxter, AJ; Broadbridge, JD; Franklin, RJ; Hampton, SL; Hudson, P; Horton, JA; Jenkins, PD; Penson, AM; Pitt, GR; Rivière, P; Robson, PA; Rooker, DP; Semple, G; Sheppard, A; Haigh, RM; Roe, MB New benzylureas as a novel series of potent, nonpeptidic vasopressin V2 receptor agonists. J Med Chem51:8124-34 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Vasopressin V2 receptor |
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| Name: | Vasopressin V2 receptor |
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| Synonyms: | ADHR | AVPR V2 | AVPR2 | Antidiuretic hormone receptor | DIR | DIR3 | Renal-type arginine vasopressin receptor | V2R | V2R_HUMAN | VASOPRESSIN V2 | Vasopressin V2 receptor | Vasopressin receptor |
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| Type: | Receptor |
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| Mol. Mass.: | 40295.28 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P30518 |
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| Residue: | 371 |
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| Sequence: | MLMASTTSAVPGHPSLPSLPSNSSQERPLDTRDPLLARAELALLSIVFVAVALSNGLVLA
ALARRGRRGHWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGPDALCRAVKYLQM
VGMYASSYMILAMTLDRHRAICRPMLAYRHGSGAHWNRPVLVAWAFSLLLSLPQLFIFAQ
RNVEGGSGVTDCWACFAEPWGRRTYVTWIALMVFVAPTLGIAACQVLIFREIHASLVPGP
SERPGGRRRGRRTGSPGEGAHVSAAVAKTVRMTLVIVVVYVLCWAPFFLVQLWAAWDPEA
PLEGAPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCARGRTPPSLGPQDESCTT
ASSSLAKDTSS
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| BDBM50246721 |
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| n/a |
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| Name | BDBM50246721 |
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| Synonyms: | 1-(4-(10,11-Dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-10-ylcarbonyl)-2-methylbenzylcarbamoyl)-L-proline-N,N-dimethylamide | CHEMBL475333 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H33N5O3 |
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| Mol. Mass. | 499.604 |
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| SMILES | CN(C)C(=O)[C@@H]1CCCN1C(=O)NCc1ccc(cc1C)C(=O)N1Cc2cccn2Cc2ccccc12 |r| |
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| Structure | 
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