| Reaction Details |
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 | Report a problem with these data |
| Target | Tubulin--tyrosine ligase |
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| Ligand | BDBM50293297 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_519880 (CHEMBL961245) |
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| Kd | 3000±n/a nM |
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| Citation |  Dal Piaz, F; Vassallo, A; Lepore, L; Tosco, A; Bader, A; De Tommasi, N Sesterterpenes as tubulin tyrosine ligase inhibitors. First insight of structure-activity relationships and discovery of new lead. J Med Chem52:3814-28 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tubulin--tyrosine ligase |
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| Name: | Tubulin--tyrosine ligase |
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| Synonyms: | TTL | TTL_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 43213.30 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_519880 |
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| Residue: | 377 |
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| Sequence: | MYTFVVRDENSSVYAEVSRLLLATGHWKRLRRDNPRFNLMLGERNRLPFGRLGHEPGLVQ
LVNYYRGADKLCRKASLVKLIKTSPELAESCTWFPESYVIYPTNLKTPVAPAQNGIQPPI
SNSRTDEREFFLASYNRKKEDGEGNVWIAKSSAGAKGEGILISSEASELLDFIDNQGQVH
VIQKYLEHPLLLEPGHRKFDIRSWVLVDHQYNIYLYREGVLRTASEPYHVDNFQDKTCHL
TNHCIQKEYSKNYGKYEEGNEMFFKEFNQYLTSALNITLESSILLQIKHIIRNCLLSVEP
AISTKHLPYQSFQLFGFDFMVDEELKVWLIEVNGAPACAQKLYAELCQGIVDIAISSVFP
PPDVEQPQTQPAAFIKL
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| BDBM50293297 |
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| n/a |
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| Name | BDBM50293297 |
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| Synonyms: | 6alpha,8alpha,15(S)-trihydroxy-23-carbossi-labd-13(14),17-dien-16(S),19-olide | CHEMBL497633 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H38O7 |
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| Mol. Mass. | 450.565 |
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| SMILES | C\C(CC[C@H]1[C@](C)(O)C[C@H](O)[C@@H]2[C@]1(C)CCC[C@@]2(C)C(O)=O)=C/[C@H](O)[C@H]1OC(=O)C=C1C |r,c:31| |
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| Structure | 
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