| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tubulin--tyrosine ligase |
|---|
| Ligand | BDBM50293300 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_519880 (CHEMBL961245) |
|---|
| Kd | 73±n/a nM |
|---|
| Citation |  Dal Piaz, F; Vassallo, A; Lepore, L; Tosco, A; Bader, A; De Tommasi, N Sesterterpenes as tubulin tyrosine ligase inhibitors. First insight of structure-activity relationships and discovery of new lead. J Med Chem52:3814-28 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tubulin--tyrosine ligase |
|---|
| Name: | Tubulin--tyrosine ligase |
|---|
| Synonyms: | TTL | TTL_HUMAN |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 43213.30 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_519880 |
|---|
| Residue: | 377 |
|---|
| Sequence: | MYTFVVRDENSSVYAEVSRLLLATGHWKRLRRDNPRFNLMLGERNRLPFGRLGHEPGLVQ
LVNYYRGADKLCRKASLVKLIKTSPELAESCTWFPESYVIYPTNLKTPVAPAQNGIQPPI
SNSRTDEREFFLASYNRKKEDGEGNVWIAKSSAGAKGEGILISSEASELLDFIDNQGQVH
VIQKYLEHPLLLEPGHRKFDIRSWVLVDHQYNIYLYREGVLRTASEPYHVDNFQDKTCHL
TNHCIQKEYSKNYGKYEEGNEMFFKEFNQYLTSALNITLESSILLQIKHIIRNCLLSVEP
AISTKHLPYQSFQLFGFDFMVDEELKVWLIEVNGAPACAQKLYAELCQGIVDIAISSVFP
PPDVEQPQTQPAAFIKL
|
|
|
|---|
| BDBM50293300 |
|---|
| n/a |
|---|
| Name | BDBM50293300 |
|---|
| Synonyms: | 8alpha-hydroxy,23alpha-O-ethyl-23,6alpha-epoxy-labd-13(14),17-dien-16(R),19-olide | CHEMBL483883 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H42O5 |
|---|
| Mol. Mass. | 446.6194 |
|---|
| SMILES | CCO[C@H]1O[C@H]2C[C@@](C)(O)[C@H](CC\C(C)=C\C[C@H]3OC(=O)C=C3C)[C@@]3(C)CCC[C@]1(C)[C@H]23 |r,c:21| |
|---|
| Structure | 
|
|---|
Search and Browse
