Reaction Details |
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Target | Type-1 angiotensin II receptor |
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Ligand | BDBM50282421 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_36953 (CHEMBL648856) |
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IC50 | 4.3±n/a nM |
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Citation | Naylor, EM; Chakravarty, PK; Costello, CA; Chang, RS; Chen, TB; Faust, KA; Lotti, VJ; Kivlighn, SD; Zingaro, GJ; Siegl, PK; Wong, PC; Carini, DJ; Wexler, RR; Patchett, AA; Greenlee, WJ Potent imidazole angiotensinII antagonists: acyl sulfonamides and acyl sulfamides as tetrazole replacements Bioorg Med Chem Lett4:69-74 (1994) Article |
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More Info.: | Get all data from this article, Assay Method |
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Type-1 angiotensin II receptor |
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Name: | Type-1 angiotensin II receptor |
Synonyms: | AGTR1 | AGTR1_RABIT | ANGIOTENSIN AT1 | Angiotensin II receptor | Angiotensin II type 1a (AT-1a) receptor |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 41009.15 |
Organism: | RABBIT |
Description: | ANGIOTENSIN AT1 AGTR1 RABBIT::P34976 |
Residue: | 359 |
Sequence: | MMLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLAVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVC
AFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFK
IIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCRIADIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSSKKPVPCFEVE
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BDBM50282421 |
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n/a |
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Name | BDBM50282421 |
Synonyms: | 3-[2'-(Cyclopropanecarbonyl-sulfamoyl)-biphenyl-4-ylmethyl]-5-ethyl-2-propyl-3H-imidazole-4-carboxylic acid | CHEMBL164059 |
Type | Small organic molecule |
Emp. Form. | C26H29N3O5S |
Mol. Mass. | 495.591 |
SMILES | CCCc1nc(CC)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)C1CC1 |
Structure |
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