| Reaction Details |
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 | Report a problem with these data |
| Target | Type-1 angiotensin II receptor |
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| Ligand | BDBM50282821 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_36161 (CHEMBL646973) |
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| IC50 | 77±n/a nM |
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| Citation |  Levin, JI; Chan, PS; Coupet, J; Thibault, L; Venkatesan, AM; Bailey, TK; Vice, G; Cobuzzi, A; Lai, F; Mellish, N Synthesis and biological evaluation of the potent isoxazolidinyl angiotensin II receptor antagonist CL332,877 and its enantiomers. Bioorg Med Chem Lett4:1709-1714 (1994) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Type-1 angiotensin II receptor |
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| Name: | Type-1 angiotensin II receptor |
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| Synonyms: | AGTR1 | AGTR1_BOVIN | Angiotensin II type 1a (AT-1a) receptor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 41107.81 |
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| Organism: | Bos taurus |
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| Description: | ChEMBL_36779 |
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| Residue: | 359 |
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| Sequence: | MILNSSTEDGIKRIQDDCPKAGRHNYIFIMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPTIIHRNVFFIENTNITVC
AFHYESQNSTLPVGLGLTKNILGFLFPFLIILTSYTLIWKTLKKAYEIQKNKPRKDDIFK
IILAIVLFFFFSWVPHQIFTFMDVLIQLGLIRDCKIEDIVDTAMPITICLAYFNNCLNPL
FYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSENGNSSTKKPAPCIEVE
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| BDBM50282821 |
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| n/a |
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| Name | BDBM50282821 |
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| Synonyms: | 2-Butyl-6-((2S,3aR)-2-methyl-hexahydro-pyrrolo[1,2-b]isoxazol-2-yl)-3-[2''-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-quinazolin-4-one | 2-Butyl-6-((2S,3aR)-2-methyl-hexahydro-pyrrolo[1,2-b]isoxazol-2-yl)-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-quinazolin-4-one; compound with NaOH | CHEMBL295174 | CHEMBL297425 | CL-332877 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H34N7O2 |
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| Mol. Mass. | 560.6693 |
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| SMILES | CCCCc1nc2ccc(cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nn[n-]n1)C1(C)CC2CCCN2O1 |
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| Structure | 
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