| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dickkopf-related protein 1 |
|---|
| Ligand | BDBM50303039 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_597250 (CHEMBL1043427) |
|---|
| EC50 | 1000±n/a nM |
|---|
| Citation |  Pelletier, JC; Lundquist, JT; Gilbert, AM; Alon, N; Bex, FJ; Bhat, BM; Bursavich, MG; Coleburn, VE; Felix, LA; Green, DM; Green, P; Hauze, DB; Kharode, YP; Lam, HS; Lockhead, SR; Magolda, RL; Matteo, JJ; Mehlmann, JF; Milligan, C; Murrills, RJ; Pirrello, J; Selim, S; Sharp, MC; Unwalla, RJ; Vera, MD; Wrobel, JE; Yaworsky, P; Bodine, PV (1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine: a wingless beta-catenin agonist that increases bone formation rate. J Med Chem52:6962-5 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dickkopf-related protein 1 |
|---|
| Name: | Dickkopf-related protein 1 |
|---|
| Synonyms: | DKK1 | DKK1_HUMAN |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 28687.93 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_597250 |
|---|
| Residue: | 266 |
|---|
| Sequence: | MMALGAAGATRVFVAMVAAALGGHPLLGVSATLNSVLNSNAIKNLPPPLGGAAGHPGSAV
SAAPGILYPGGNKYQTIDNYQPYPCAEDEECGTDEYCASPTRGGDAGVQICLACRKRRKR
CMRHAMCCPGNYCKNGICVSSDQNHFRGEIEETITESFGNDHSTLDGYSRRTTLSSKMYH
TKGQEGSVCLRSSDCASGLCCARHFWSKICKPVLKEGQVCTKHRRKGSHGLEIFQRCYCG
EGLSCRIQKDHHQASNSSRLHTCQRH
|
|
|
|---|
| BDBM50303039 |
|---|
| n/a |
|---|
| Name | BDBM50303039 |
|---|
| Synonyms: | 4-(4-(naphthalen-2-yl)pyrimidin-2-ylamino)benzenesulfonamide | CHEMBL569046 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H16N4O2S |
|---|
| Mol. Mass. | 376.432 |
|---|
| SMILES | NS(=O)(=O)c1ccc(Nc2nccc(n2)-c2ccc3ccccc3c2)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
