| Reaction Details |
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 | Report a problem with these data |
| Target | Procathepsin L |
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| Ligand | BDBM50306670 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_611257 (CHEMBL1068286) |
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| IC50 | 4570±n/a nM |
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| Citation |  Kishore Kumar, GD; Chavarria, GE; Charlton-Sevcik, AK; Arispe, WM; Macdonough, MT; Strecker, TE; Chen, SE; Siim, BG; Chaplin, DJ; Trawick, ML; Pinney, KG Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors. Bioorg Med Chem Lett20:1415-9 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Procathepsin L |
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| Name: | Procathepsin L |
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| Synonyms: | CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein |
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| Type: | Enzyme |
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| Mol. Mass.: | 37557.19 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Purchased from Calbiochem (San Diego, CA). |
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| Residue: | 333 |
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| Sequence: | MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE
LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW
REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG
GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVA
TVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKN
SWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
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| BDBM50306670 |
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| n/a |
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| Name | BDBM50306670 |
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| Synonyms: | CHEMBL599871 | [(4-Bromo-phenyl)-p-tolyl-ketone]thiosemicarbazone |
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| Type | Small organic molecule |
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| Emp. Form. | C15H14BrN3S |
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| Mol. Mass. | 348.261 |
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| SMILES | Cc1ccc(cc1)C(=NNC(N)=S)c1ccc(Br)cc1 |w:8.9| |
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| Structure | 
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