Reaction Details |
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Target | Substance-P receptor |
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Ligand | BDBM50308389 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_613946 (CHEMBL1068986) |
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Ki | 64±n/a nM |
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Citation | Fransson, R; Botros, M; Sköld, C; Nyberg, F; Lindeberg, G; Hallberg, M; Sandström, A Discovery of dipeptides with high affinity to the specific binding site for substance P1-7. J Med Chem53:2383-9 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Substance-P receptor |
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Name: | Substance-P receptor |
Synonyms: | NK-1 receptor | NK-1R | NK1 Receptor | NK1R_RAT | Neurokinin 1 receptor | Neurokinin NK1 | SPR | Substance-P receptor | Tac1r | Tachykinin receptor 1 | Tacr1 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 46371.54 |
Organism: | Rattus norvegicus (rat) |
Description: | Competition binding assays were carried out using membrane preparations from transfected CHO cells that constitutively expressed the rat NK1 receptor. |
Residue: | 407 |
Sequence: | MDNVLPMDSDLFPNISTNTSESNQFVQPTWQIVLWAAAYTVIVVTSVVGNVVVIWIILAH
KRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVC
MIEWPEHPNRTYEKAYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHVFFLLPYINPDLYLKKFIQQVYLASMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQSSVYKVSRLETTIST
VVGAHEEEPEEGPKATPSSLDLTSNGSSRSNSKTMTESSSFYSNMLA
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BDBM50308389 |
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n/a |
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Name | BDBM50308389 |
Synonyms: | (D)-Phe-(D)-Phe-NH2 | CHEMBL590276 |
Type | Small organic molecule |
Emp. Form. | C18H21N3O2 |
Mol. Mass. | 311.3782 |
SMILES | N[C@H](Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(N)=O |r| |
Structure |
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