| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin K |
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| Ligand | BDBM50313517 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_617674 (CHEMBL1101470) |
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| IC50 | 2500±n/a nM |
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| Citation |  Rankovic, Z; Cai, J; Fradera, X; Dempster, M; Mistry, A; Mitchell, A; Long, C; Hamilton, E; King, A; Boucharens, S; Jamieson, C; Gillespie, J; Cumming, I; Uitdehaag, J; van Zeeland, M Dioxo-triazines as a novel series of cathepsin K inhibitors. Bioorg Med Chem Lett20:1488-90 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cathepsin K |
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| Name: | Cathepsin K |
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| Synonyms: | CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X |
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| Type: | Enzyme |
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| Mol. Mass.: | 36975.68 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P43235 |
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| Residue: | 329 |
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| Sequence: | MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIH
NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVD
YRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGG
YMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVA
RVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGE
NWGNKGYILMARNKNNACGIANLASFPKM
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| BDBM50313517 |
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| n/a |
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| Name | BDBM50313517 |
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| Synonyms: | 4-ethyl-3,5-dioxo-2-(3-(trifluoromethyl)phenyl)-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile | CHEMBL1078995 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H9F3N4O2 |
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| Mol. Mass. | 310.2314 |
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| SMILES | CCn1c(=O)c(nn(-c2cccc(c2)C(F)(F)F)c1=O)C#N |
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| Structure | 
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