| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 1 |
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| Ligand | BDBM50320752 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_639141 (CHEMBL1167402) |
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| IC50 | 18000±n/a nM |
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| Citation |  Kiyokawa, S; Hirata, Y; Nagaoka, Y; Shibano, M; Taniguchi, M; Yasuda, M; Baba, K; Uesato, S New orally bioavailable 2-aminobenzamide-type histone deacetylase inhibitor possessing a (2-hydroxyethyl)(4-(thiophen-2-yl)benzyl)amino group. Bioorg Med Chem18:3925-33 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 1 |
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| Name: | Histone deacetylase 1 |
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| Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 55090.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13547 |
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| Residue: | 482 |
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| Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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| BDBM50320752 |
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| n/a |
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| Name | BDBM50320752 |
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| Synonyms: | CHEMBL1163807 | N-(2-Aminophenyl)-4-(((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methylthio)methyl)benzamide |
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| Type | Small organic molecule |
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| Emp. Form. | C23H22N2O3S |
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| Mol. Mass. | 406.497 |
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| SMILES | Nc1ccccc1NC(=O)c1ccc(CSCC2COc3ccccc3O2)cc1 |
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| Structure | 
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