Reaction Details |
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Target | Steroid 17-alpha-hydroxylase/17,20 lyase |
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Ligand | BDBM50322793 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_649579 (CHEMBL1219277) |
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IC50 | 52±n/a nM |
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Citation | Hu, Q; Jagusch, C; Hille, UE; Haupenthal, J; Hartmann, RW Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prostate cancer. J Med Chem53:5749-58 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Steroid 17-alpha-hydroxylase/17,20 lyase |
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Name: | Steroid 17-alpha-hydroxylase/17,20 lyase |
Synonyms: | CP17A_HUMAN | CYP17 | CYP17A1 | CYPXVII | Cytochrome P450 17A1 | Cytochrome P450 C17 (CYP17 ) | Cytochrome P450 C17 (CYP17) | Cytochrome P450 CYP17 | Cytochrome P450-C17 | Cytochrome P450-C17 (CYP17) | P450-C17 | S17AH | Steroid 17-alpha-Monooxygenase (CYP17) | Steroid 17-alpha-hydroxylase/17,20 lyase | Steroid 17-alpha-monooxygenase | cytochrome P450 monooxygenase 17 alpha hydroxylase/17,20-lyase (CYP17) |
Type: | Enzyme |
Mol. Mass.: | 57382.42 |
Organism: | Homo sapiens (Human) |
Description: | E.coli expressing human CYP17 |
Residue: | 508 |
Sequence: | MWELVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKY
GPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAH
WQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVIS
LICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRN
DLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIF
GAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREV
LRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNP
AGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIP
KVVFLIDSFKVKIKVRQAWREAQAEGST
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BDBM50322793 |
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n/a |
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Name | BDBM50322793 |
Synonyms: | 4'-(Pyridin-4-ylmethyl)biphenyl-3,4-diol | CHEMBL1172779 |
Type | Small organic molecule |
Emp. Form. | C18H15NO2 |
Mol. Mass. | 277.3172 |
SMILES | Oc1ccc(cc1O)-c1ccc(Cc2ccncc2)cc1 |
Structure |
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