| Reaction Details |
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 | Report a problem with these data |
| Target | Polyamine deacetylase HDAC10 |
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| Ligand | BDBM50326168 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_658916 (CHEMBL1246055) |
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| IC50 | 23900±n/a nM |
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| Citation |  Conti, P; Tamborini, L; Pinto, A; Sola, L; Ettari, R; Mercurio, C; De Micheli, C Design and synthesis of novel isoxazole-based HDAC inhibitors. Eur J Med Chem45:4331-8 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Polyamine deacetylase HDAC10 |
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| Name: | Polyamine deacetylase HDAC10 |
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| Synonyms: | HD10 | HDA10_HUMAN | HDAC10 | Histone deacetylase | Histone deacetylase 10 | Human HDAC10 |
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| Type: | Chromatin regulator; hydrolase; repressor |
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| Mol. Mass.: | 71431.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q969S8 |
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| Residue: | 669 |
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| Sequence: | MGTALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEEL
GLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTG
AVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQ
YLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVA
AFLHLLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQATPECFAHLTQLLQVLAGGRVCAV
LEGGYHLESLAESVCMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQ
DVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPD
ITLVLPPDVIQQEASALREETEAWARPHESLAREEALTALGKLLYLLDGMLDGQVNSGIA
ATPASAAAATLDVAVRRGLSHGAQRLLCVALGQLDRPPDLAHDGRSLWLNIRGKEAAALS
MFHVSTPLPVMTGGFLSCILGLVLPLAYGFQPDLVLVALGPGHGLQGPHAALLAAMLRGL
AGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWKM
LQCHPHLVA
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| BDBM50326168 |
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| n/a |
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| Name | BDBM50326168 |
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| Synonyms: | CHEMBL1243289 | N-Hydroxy-5-[5-oxo-5-(phenylamino)pentyl]-4,5-dihydroisoxazole-3-carboxamide |
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| Type | Small organic molecule |
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| Emp. Form. | C15H19N3O4 |
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| Mol. Mass. | 305.3291 |
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| SMILES | ONC(=O)C1=NOC(CCCCC(=O)Nc2ccccc2)C1 |t:4| |
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| Structure | 
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