Reaction Details |
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Target | S-methyl-5'-thioadenosine phosphorylase |
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Ligand | BDBM50326399 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_657428 (CHEMBL1246404) |
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Ki | 0.800±n/a nM |
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Citation | Longshaw, AI; Adanitsch, F; Gutierrez, JA; Evans, GB; Tyler, PC; Schramm, VL Design and synthesis of potent"sulfur-free" transition state analogue inhibitors of 5'-methylthioadenosine nucleosidase and 5'-methylthioadenosine phosphorylase. J Med Chem53:6730-46 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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S-methyl-5'-thioadenosine phosphorylase |
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Name: | S-methyl-5'-thioadenosine phosphorylase |
Synonyms: | 5'-Methylthioadenosine phosphorylase (MTAP) | MSAP | MTA phosphorylase | MTAP | MTAP_HUMAN | MTAPase | Methylthioadenosine Phosphorylase (MTAP) | S-methyl-5 -thioadenosine phosphorylase |
Type: | Enzyme |
Mol. Mass.: | 31239.23 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 283 |
Sequence: | MASGTTTTAVKIGIIGGTGLDDPEILEGRTEKYVDTPFGKPSDALILGKIKNVDCVLLAR
HGRQHTIMPSKVNYQANIWALKEEGCTHVIVTTACGSLREEIQPGDIVIIDQFIDRTTMR
PQSFYDGSHSCARGVCHIPMAEPFCPKTREVLIETAKKLGLRCHSKGTMVTIEGPRFSSR
AESFMFRTWGADVINMTTVPEVVLAKEAGICYASIAMATDYDCWKEHEEAVSVDRVLKTL
KENANKAKSLLLTTIPQIGSTEWSETLHNLKNMAQFSVLLPRH
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BDBM50326399 |
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n/a |
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Name | BDBM50326399 |
Synonyms: | (+/-)-trans-4-Butyl-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxypyrrolidine | (3R,4S)-4-Butyl-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxypyrrolidine | CHEMBL1243249 |
Type | Small organic molecule |
Emp. Form. | C15H23N5O |
Mol. Mass. | 289.376 |
SMILES | CCCC[C@H]1CN(Cc2c[nH]c3c(N)ncnc23)C[C@@H]1O |r| |
Structure |
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