| Reaction Details |
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 | Report a problem with these data |
| Target | Metabotropic glutamate receptor 1 |
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| Ligand | BDBM50326794 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_661795 (CHEMBL1252028) |
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| EC50 | >100000±n/a nM |
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| Citation |  Stanley, NJ; Hutchinson, MR; Kvist, T; Nielsen, B; Mathiesen, JM; Bräuner-Osborne, H; Avery, TD; Tiekink, ER; Pedersen, DS; Irvine, RJ; Abell, AD; Taylor, DK A new metabotropic glutamate receptor agonist with in vivo anti-allodynic activity. Bioorg Med Chem18:6089-98 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Metabotropic glutamate receptor 1 |
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| Name: | Metabotropic glutamate receptor 1 |
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| Synonyms: | GPRC1A | GRM1 | GRM1_HUMAN | MGLUR1 | Metabotropic Glutamate 1a | metabotropic glutamate 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 132358.19 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13255 |
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| Residue: | 1194 |
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| Sequence: | MVGLLLFFFPAIFLEVSLLPRSPGRKVLLAGASSQRSVARMDGDVIIGALFSVHHQPPAE
KVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSI
EFIRDSLISIRDEKDGINRCLPDGQSLPPGRTKKPIAGVIGPGSSSVAIQVQNLLQLFDI
PQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESG
MDAFKELAAQEGLCIAHSDKIYSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTVRGLL
SAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLD
TNTRNPWFPEFWQHRFQCRLPGHLLENPNFKRICTGNESLEENYVQDSKMGFVINAIYAM
AHGLQNMHHALCPGHVGLCDAMKPIDGSKLLDFLIKSSFIGVSGEEVWFDEKGDAPGRYD
IMNLQYTEANRYDYVHVGTWHEGVLNIDDYKIQMNKSGVVRSVCSEPCLKGQIKVIRKGE
VSCCWICTACKENEYVQDEFTCKACDLGWWPNADLTGCEPIPVRYLEWSNIESIIAIAFS
CLGILVTLFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQ
RLLVGLSSAMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVIIASILISVQLTL
VVTLIIMEPPMPILSYPSIKEVYLICNTSNLGVVAPLGYNGLLIMSCTYYAFKTRNVPAN
FNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITTCFAVSLSVTVALGCMFTPKMYIIIA
KPERNVRSAFTTSDVVRMHVGDGKLPCRSNTFLNIFRRKKAGAGNANSNGKSVSWSEPGG
GQVPKGQHMWHRLSVHVKTNETACNQTAVIKPLTKSYQGSGKSLTFSDTSTKTLYNVEEE
EDAQPIRFSPPGSPSMVVHRRVPSAATTPPLPSHLTAEETPLFLAEPALPKGLPPPLQQQ
QQPPPQQKSLMDQLQGVVSNFSTAIPDFHAVLAGPGGPGNGLRSLYPPPPPPQHLQMLPL
QLSTFGEELVSPPADDDDDSERFKLLQEYVYEHEREGNTEEDELEEEEEDLQAASKLTPD
DSPALTPPSPFRDSVASGSSVPSSPVSESVLCTPPNVSYASVILRDYKQSSSTL
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| BDBM50326794 |
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| n/a |
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| Name | BDBM50326794 |
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| Synonyms: | (+/-)(1R,2S,3S)-3-[(S)-amino(carboxy)-methyl]-1,10-bi(cyclopropyl)-2-carboxylic acid | CHEMBL1253501 |
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| Type | Small organic molecule |
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| Emp. Form. | C9H13NO4 |
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| Mol. Mass. | 199.2038 |
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| SMILES | N[C@@H]([C@H]1[C@@H](C2CC2)[C@@H]1C(O)=O)C(O)=O |r| |
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| Structure | 
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