| Reaction Details |
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 | Report a problem with these data |
| Target | Renin |
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| Ligand | BDBM50327284 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_664344 (CHEMBL1259493) |
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| IC50 | 0.52±n/a nM |
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| Citation |  Lacombe, P; Aspiotis, R; Bayly, C; Chen, A; Dubé, D; Fortin, R; Gallant, M; Juteau, H; Liu, S; McKay, D; Roy, P; Wu, T Identification of a new biaryl scaffold generating potent renin inhibitors. Bioorg Med Chem Lett20:5822-6 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Renin |
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| Name: | Renin |
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| Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 45058.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 406 |
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| Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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| BDBM50327284 |
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| n/a |
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| Name | BDBM50327284 |
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| Synonyms: | 3-(4-(2-(2,6-dichloro-4-methylphenoxy)ethoxy)phenyl)-2-(2',3-dichlorobiphenyl-4-yl)propan-1-amine | CHEMBL1257460 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H27Cl4NO2 |
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| Mol. Mass. | 575.353 |
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| SMILES | Cc1cc(Cl)c(OCCOc2ccc(CC(CN)c3ccc(cc3Cl)-c3ccccc3Cl)cc2)c(Cl)c1 |
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| Structure | 
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