Reaction Details |
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Target | Renin |
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Ligand | BDBM50328913 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_673988 (CHEMBL1275165) |
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IC50 | 0.15±n/a nM |
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Citation | Corminboeuf, O; Bezençon, O; Remen, L; Grisostomi, C; Richard-Bildstein, S; Bur, D; Prade, L; Strickner, P; Hess, P; Fischli, W; Steiner, B; Treiber, A Piperidine-based renin inhibitors: upper chain optimization. Bioorg Med Chem Lett20:6291-6 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Renin |
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Name: | Renin |
Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 45058.99 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 406 |
Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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BDBM50328913 |
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n/a |
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Name | BDBM50328913 |
Synonyms: | CHEMBL1269751 | methyl 4-chloro-3-(((3R,4S)-4-(4-((3-(2-chloro-3,6-difluorophenyl)isoxazol-5-yl)methoxy)phenyl)-N-cyclopropylpiperidine-3-carboxamido)methyl)benzylcarbamate |
Type | Small organic molecule |
Emp. Form. | C35H34Cl2F2N4O5 |
Mol. Mass. | 699.571 |
SMILES | COC(=O)NCc1ccc(Cl)c(CN(C2CC2)C(=O)[C@H]2CNCC[C@@H]2c2ccc(OCc3cc(no3)-c3c(F)ccc(F)c3Cl)cc2)c1 |r| |
Structure |
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