| Reaction Details |
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 | Report a problem with these data |
| Target | Stearoyl-CoA desaturase |
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| Ligand | BDBM50329985 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_676021 (CHEMBL1272959) |
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| IC50 | 15±n/a nM |
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| Citation |  Powell, DA; Ramtohul, Y; Lebrun, ME; Oballa, R; Bhat, S; Falgueyret, JP; Guiral, S; Huang, Z; Skorey, K; Tawa, P; Zhang, L 2-Aryl benzimidazoles: human SCD1-specific stearoyl coenzyme-A desaturase inhibitors. Bioorg Med Chem Lett20:6366-9 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Stearoyl-CoA desaturase |
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| Name: | Stearoyl-CoA desaturase |
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| Synonyms: | Acyl-CoA desaturase | FADS5 | SCD | SCD1 | SCDOS | SCD_HUMAN | Stearoyl-CoA (SCD1) | Stearoyl-CoA desaturase 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41537.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O00767 |
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| Residue: | 359 |
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| Sequence: | MPAHLLQDDISSSYTTTTTITAPPSRVLQNGGDKLETMPLYLEDDIRPDIKDDIYDPTYK
DKEGPSPKVEYVWRNIILMSLLHLGALYGITLIPTCKFYTWLWGVFYYFVSALGITAGAH
RLWSHRSYKARLPLRLFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFS
HVGWLLVRKHPAVKEKGSTLDLSDLEAEKLVMFQRRYYKPGLLMMCFILPTLVPWYFWGE
TFQNSVFVATFLRYAVVLNATWLVNSAAHLFGYRPYDKNISPRENILVSLGAVGEGFHNY
HHSFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAILARIKRTGDGNYKSG
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| BDBM50329985 |
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| n/a |
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| Name | BDBM50329985 |
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| Synonyms: | 2-(3'-chlorobiphenyl-4-yl)-6-(methylsulfonyl)-1H-benzo[d]imidazole | CHEMBL1271648 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H15ClN2O2S |
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| Mol. Mass. | 382.863 |
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| SMILES | CS(=O)(=O)c1ccc2nc([nH]c2c1)-c1ccc(cc1)-c1cccc(Cl)c1 |
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| Structure | 
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