| Reaction Details |
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 | Report a problem with these data |
| Target | Bcl-2-related protein A1 |
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| Ligand | BDBM50313353 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_676082 (CHEMBL1273076) |
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| IC50 | 2400±n/a nM |
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| Citation |  Cashman, JR; MacDonald, M; Ghirmai, S; Okolotowicz, KJ; Sergienko, E; Brown, B; Garcia, X; Zhai, D; Dahl, R; Reed, JC Inhibition of Bfl-1 with N-aryl maleimides. Bioorg Med Chem Lett20:6560-4 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bcl-2-related protein A1 |
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| Name: | Bcl-2-related protein A1 |
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| Synonyms: | B2LA1_HUMAN | BCL2A1 | BCL2L5 | BFL1 | Bcl-2-like protein 5 | GRS | HBPA1 | Hemopoietic-specific early response protein | Protein BFL-1 | Protein GRS |
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| Type: | Apoptosis regulator protein |
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| Mol. Mass.: | 20130.01 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 175 |
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| Sequence: | MTDCEFGYIYRLAQDYLQCVLQIPQPGSGPSKTSRVLQNVAFSVQKEVEKNLKSCLDNVN
VVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAFEGILIKKLLRQQIAPDVDTYKEISY
FVAEFIMNNTGEWIRQNGGWENGFVKKFEPKSGWMTFLEVTGKICEMLSLLKQYC
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| BDBM50313353 |
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| n/a |
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| Name | BDBM50313353 |
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| Synonyms: | 6-(cyclohexyl(cyclopropylmethyl)amino)-N-(6-methyl-1H-indazol-5-yl)pyrimidine-4-carboxamide | CHEMBL1080382 | US9150519, 1-47 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H28N6O |
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| Mol. Mass. | 404.508 |
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| SMILES | Cc1cc2[nH]ncc2cc1NC(=O)c1cc(ncn1)N(CC1CC1)C1CCCCC1 |
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| Structure | 
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