Reaction Details |
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Target | Bcl-2-related protein A1 |
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Ligand | BDBM39146 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_676082 (CHEMBL1273076) |
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IC50 | 300±n/a nM |
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Citation | Cashman, JR; MacDonald, M; Ghirmai, S; Okolotowicz, KJ; Sergienko, E; Brown, B; Garcia, X; Zhai, D; Dahl, R; Reed, JC Inhibition of Bfl-1 with N-aryl maleimides. Bioorg Med Chem Lett20:6560-4 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Bcl-2-related protein A1 |
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Name: | Bcl-2-related protein A1 |
Synonyms: | B2LA1_HUMAN | BCL2A1 | BCL2L5 | BFL1 | Bcl-2-like protein 5 | GRS | HBPA1 | Hemopoietic-specific early response protein | Protein BFL-1 | Protein GRS |
Type: | Apoptosis regulator protein |
Mol. Mass.: | 20130.01 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 175 |
Sequence: | MTDCEFGYIYRLAQDYLQCVLQIPQPGSGPSKTSRVLQNVAFSVQKEVEKNLKSCLDNVN
VVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAFEGILIKKLLRQQIAPDVDTYKEISY
FVAEFIMNNTGEWIRQNGGWENGFVKKFEPKSGWMTFLEVTGKICEMLSLLKQYC
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BDBM39146 |
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n/a |
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Name | BDBM39146 |
Synonyms: | 3-chloranyl-1-(3,4-dichlorophenyl)-4-[4-[2-(2-hydroxyethyloxy)ethyl]piperazin-1-yl]pyrrole-2,5-dione | 3-chloro-1-(3,4-dichlorophenyl)-4-(4-(2-(2-hydroxyethoxy)ethyl)piperazin-1-yl)-1H-pyrrole-2,5-dione | 3-chloro-1-(3,4-dichlorophenyl)-4-[4-[2-(2-hydroxyethoxy)ethyl]-1-piperazinyl]pyrrole-2,5-dione | 3-chloro-1-(3,4-dichlorophenyl)-4-[4-[2-(2-hydroxyethoxy)ethyl]piperazin-1-yl]pyrrole-2,5-dione | 3-chloro-1-(3,4-dichlorophenyl)-4-[4-[2-(2-hydroxyethoxy)ethyl]piperazino]-3-pyrroline-2,5-quinone | CHEMBL1272154 | MLS-0090856.0001 | cid_16654652 |
Type | Small organic molecule |
Emp. Form. | C18H20Cl3N3O4 |
Mol. Mass. | 448.728 |
SMILES | OCCOCCN1CCN(CC1)C1=C(Cl)C(=O)N(C1=O)c1ccc(Cl)c(Cl)c1 |c:13| |
Structure |
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