| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Aldehyde oxidase 1 |
|---|
| Ligand | BDBM50017716 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_696366 (CHEMBL1640079) |
|---|
| IC50 | 1100±n/a nM |
|---|
| Citation |  Pryde, DC; Dalvie, D; Hu, Q; Jones, P; Obach, RS; Tran, TD Aldehyde oxidase: an enzyme of emerging importance in drug discovery. J Med Chem53:8441-60 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Aldehyde oxidase 1 |
|---|
| Name: | Aldehyde oxidase 1 |
|---|
| Synonyms: | AOXA_RAT | Aldehyde oxidase | Ao | Aox1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 146930.28 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_696366 |
|---|
| Residue: | 1333 |
|---|
| Sequence: | MDPPQLLFYVNGQKVVENNVDPEMMLLPYLRKNLRLTGTKYGCGGGGCGACTVMISRYNP
STKSIRHHPVNACLTPICSLYGTAVTTVEGIGNTRTRLHPVQERIAKCHSTQCGFCTPGM
VMSMYALLRNHPEPSLDQLTDALGGNLCRCTGYRPIIDACKTFCRASGCCESKENGVCCL
DQGINGSAEFQEGDETSPELFSEKEFQPLDPTQELIFPPELMRIAEKQPPKTRVFYSNRM
TWISPVTLEELVEAKFKYPGAPIVMGYTSVGPEVKFKGVFHPIIISPDRIEELSIINQTG
DGLTLGAGLSLDQVKDILTDVVQKLPEETTQTYRALLKHLRTLAGSQIRNMASLGGHIVS
RHLDSDLNPLLAVGNCTLNLLSKDGKRQIPLSEQFLRKCPDSDLKPQEVLVSVNIPCSRK
WEFVSAFRQAQRQQNALAIVNSGMRVLFREGGGVIKELSILYGGVGPTTIGAKNSCQKLI
GRPWNEEMLDTACRLVLDEVTLAGSAPGGKVEFKRTLIISFLFKFYLEVLQGLKREDPGH
YPSLTNNYESALEDLHSKHHWRTLTHQNVDSMQLPQDPIGRPIMHLSGIKHATGEAIYCD
DMPAVDRELFLTFVTSSRAHAKIVSIDLSEALSLPGVVDIITADHLQDATTFGTETLLAT
DKVHCVGQLVCAVIADSETRAKQAAKHVKVVYRDLEPLILTIEEAIQHKSFFESERKLEC
GNVDEAFKIADQILEGEIHIGGQEHFYMETQSMLVVPKGEDGEIDIYVSTQFPKHIQDIV
AATLKLSVNKVMCHVRRVGGAFGGKVGKTSIMAAITAFAASKHGRAVRCTLERGEDMLIT
GGRHPYLGKYKVGFMRDGRIVALDVEHYCNGGSSLDESLWVIEMGLLKMDNAYKFPNLRC
RGWACRTNLPSHTALRGFGFPQAGLVTEACVTEVAIRCGLSPEQVRTINMYKQIDNTHYK
QEFSAKTLFECWRECMAKCSYSERKTAVGKFNAENSWKKRGMAVIPLKFPVGVGSVAMGQ
AAALVHIYLDGSALVSHGGIEMGQGVHTKMIQVVSRELKMPMSSVHLRGTSTETVPNTNA
SGGSVVADLNGLAVKDACQTLLKRLEPIISKNPQGTWKDWAQTAFDQSVSLSAVGYFRGY
ESNINWEKGEGHPFEYFVYGAACSEVEIDCLTGDHKNIRTDIVMDVGHSINPALDIGQVE
GAFIQGMGLYTIEELSYSPQGILYSRGPNQYKIPAICDIPTEMHISFLPPSEHSNTLYSS
KGLGESGVFLGCSVFFAIHDAVRAARQERGISGPWKLTSPLTPEKIRMACEDKFTKMIPR
DEPGSYVPWNIPV
|
|
|
|---|
| BDBM50017716 |
|---|
| n/a |
|---|
| Name | BDBM50017716 |
|---|
| Synonyms: | 2,2-Diphenyl-pentanoic acid 2-diethylamino-ethyl ester | 2-(diethylamino)ethyl 2,2-diphenylpentanoate | 2-Benzhydryl-pentanoic acid 2-diethylamino-ethyl ester | CHEMBL282567 | PROADIFEN HYDROCHLORIDE |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H31NO2 |
|---|
| Mol. Mass. | 353.4977 |
|---|
| SMILES | CCCC(C(=O)OCCN(CC)CC)(c1ccccc1)c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
