| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Aldehyde oxidase 1 |
|---|
| Ligand | BDBM50130273 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_696369 (CHEMBL1640082) |
|---|
| IC50 | 3600±n/a nM |
|---|
| Citation |  Pryde, DC; Dalvie, D; Hu, Q; Jones, P; Obach, RS; Tran, TD Aldehyde oxidase: an enzyme of emerging importance in drug discovery. J Med Chem53:8441-60 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Aldehyde oxidase 1 |
|---|
| Name: | Aldehyde oxidase 1 |
|---|
| Synonyms: | AOX1 | AOXA_MACFA | Aldehyde oxidase |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 147702.30 |
|---|
| Organism: | Macaca fascicularis |
|---|
| Description: | ChEMBL_696369 |
|---|
| Residue: | 1338 |
|---|
| Sequence: | MDRASELLFYVNGRKVIEKNVDPETMLLPYLRKKLRLTGTKYGCGGGGCGACTVMISRYN
PITNRIRHHPANACLIPICSLYGTAVTTVEGIGSTHTRIHPVQERIAKCHGTQCGFCTPG
MVMSIYTLLRNHPEPTLDQLTDALGGNLCRCTGYRPIIDACKTFCETSGCCQSKENGVCC
LDQRINGLPEFEEGSKTSPKLFAEEEFLPLDPTQELIFPPELMIMAEKQPQRTRVFGSER
MMWFSPVTLKELLEFKFKYPQAPVIMGNTSVGPQMKFKGVFHPVIISPDRIEELSVVNHT
HNGLTLGAGLSLAQVKDILADVVQKLPGEKTQTYHALLKHLGTLAGSQIRNMASLGGHII
SRHPDSDLNPILAVGNCTLNLLSKEGKRQIPLNEQFLSKCPNADLKPQEILVSVNIPYSR
KLEFVSAFRQAQRQENALAIVNSGMRVFFGEGHGIIRELSISYGGVGPATICAKNSCQKL
IGRHWNEEMLDTACRLVLEEVSLSGSAPGGRVEFKRTLIISFLFKFYLEVSQILKKMDPI
RYPSLADKHESALEDLHSKHHCSTLKYQHMGPKQHPEDPIGHPIMHLSGVKHATGEAIYC
DDMPLVDQELFLTFVTSSRAHAKIVSIDLSEALSMPGVVDVITAEHLSDVNSFCFFTEAE
EFLATDKVFCVGQLVCAVLADSEVQAKRAAKQVKIVYQDLEPLILTIKEAIQHNSFFEPE
RKLEYGNVDEAFKVVDQILEGEIHMGGQEHFYMETQSMLVVPKGEDQEMDVYVSTQFPKY
IQDIVASTLKLPANKVMCHVKRVGGAFGGKAFKTGVIAAVTAFAANKHGRAVRCVLERGE
DMLITGGRHPYLGKYKAGFMNDGRILALDMEHYSNAGNSLDESLLVIEMGLLKMDNAYKF
PNLRCRGWACRTNLPSNTAFRGFGFPQAGLITESCIMEVAAKCGLSPEKVRMINMYKEID
QTPYKQEINAKNLIQCWRECMAVSSYSLRKAAVEKFNAENYWKKKGLAMVPLKYPVGLGS
RAAGQAAALVHIYLDGSVLVTHGGIEMGQGVHTKMIQVVSRELGMPISNVHLRGTSTETV
PNANVSGGSVVADLNGLAVKDACQTLLKRLEPIISKNPKGTWKDWAQTAFDESISLSAVG
YFRGYESDINWEKGEGHPFEYFVYGAACSEVEIDCLTGDHKNIRTDIVMDVGCSINPAID
IGQIEGAFIQGMGLYTIEELNYSPQGVLHTRGPDQYKIPAICDTPTEFHISLLPPSENSN
TLYSSKGLGESGVFLGCSVFFAIHDAVSAARRERGLHGPLSLNSPLTPEKIRMACEDKFT
KMIPRDEPGSCVPWNVPI
|
|
|
|---|
| BDBM50130273 |
|---|
| n/a |
|---|
| Name | BDBM50130273 |
|---|
| Synonyms: | 2-(4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-1-piperazinyl)ethanol | 2-chloro-10-(3-(4-(2-hydroxyethyl)piperazin-1-yl)propyl)phenothiazine | 2-{4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]piperazin-1-yl}ethanol | 4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-1-piperazineethanol | 4-[3-(2-chlorophenothiazin-10-yl)propyl]-1-piperazineethanol | CHEMBL567 | Chlorpiprazine | PERPHENAZINE | Perfenazine | Perphenazin | Trilafon | gamma-(4-(beta-hydroxyethyl)piperazin-1-yl)propyl-2-chlorophenothiazine |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H26ClN3OS |
|---|
| Mol. Mass. | 403.969 |
|---|
| SMILES | OCCN1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc23)CC1 |
|---|
| Structure | 
|
|---|
Search and Browse
