| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Protein-glutamine gamma-glutamyltransferase 2 |
|---|
| Ligand | BDBM50342559 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_744966 (CHEMBL1771981) |
|---|
| Ki | 11000±n/a nM |
|---|
| Citation |  Klöck, C; Jin, X; Choi, K; Khosla, C; Madrid, PB; Spencer, A; Raimundo, BC; Boardman, P; Lanza, G; Griffin, JH Acylideneoxoindoles: a new class of reversible inhibitors of human transglutaminase 2. Bioorg Med Chem Lett21:2692-6 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Protein-glutamine gamma-glutamyltransferase 2 |
|---|
| Name: | Protein-glutamine gamma-glutamyltransferase 2 |
|---|
| Synonyms: | Protein-glutamine gamma-glutamyltransferase | Protein-glutamine gamma-glutamyltransferase 2 (TG2) | TGM2 | TGM2_HUMAN | Tissue transglutaminase | Tissue transglutaminase (TG2) | Transglutaminase 2 (TGM2) | Transglutaminase C | Transglutaminase-2 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 77309.30 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P21980 |
|---|
| Residue: | 687 |
|---|
| Sequence: | MAEELVLERCDLELETNGRDHHTADLCREKLVVRRGQPFWLTLHFEGRNYEASVDSLTFS
VVTGPAPSQEAGTKARFPLRDAVEEGDWTATVVDQQDCTLSLQLTTPANAPIGLYRLSLE
ASTGYQGSSFVLGHFILLFNAWCPADAVYLDSEEERQEYVLTQQGFIYQGSAKFIKNIPW
NFGQFEDGILDICLILLDVNPKFLKNAGRDCSRRSSPVYVGRVVSGMVNCNDDQGVLLGR
WDNNYGDGVSPMSWIGSVDILRRWKNHGCQRVKYGQCWVFAAVACTVLRCLGIPTRVVTN
YNSAHDQNSNLLIEYFRNEFGEIQGDKSEMIWNFHCWVESWMTRPDLQPGYEGWQALDPT
PQEKSEGTYCCGPVPVRAIKEGDLSTKYDAPFVFAEVNADVVDWIQQDDGSVHKSINRSL
IVGLKISTKSVGRDEREDITHTYKYPEGSSEEREAFTRANHLNKLAEKEETGMAMRIRVG
QSMNMGSDFDVFAHITNNTAEEYVCRLLLCARTVSYNGILGPECGTKYLLNLNLEPFSEK
SVPLCILYEKYRDCLTESNLIKVRALLVEPVINSYLLAERDLYLENPEIKIRILGEPKQK
RKLVAEVSLQNPLPVALEGCTFTVEGAGLTEEQKTVEIPDPVEAGEEVKVRMDLLPLHMG
LHKLVVNFESDKLKAVKGFRNVIIGPA
|
|
|
|---|
| BDBM50342559 |
|---|
| n/a |
|---|
| Name | BDBM50342559 |
|---|
| Synonyms: | 1,1'-(4,6-dimethyl-1,3-phenylene)bis(methylene)diindoline-2,3-dione | CHEMBL1770391 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H20N2O4 |
|---|
| Mol. Mass. | 424.448 |
|---|
| SMILES | Cc1cc(C)c(CN2C(=O)C(=O)c3ccccc23)cc1CN1C(=O)C(=O)c2ccccc12 |
|---|
| Structure | 
|
|---|
Search and Browse
