Reaction Details |
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Target | Melanocortin receptor 4 |
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Ligand | BDBM50329962 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_755005 (CHEMBL1805907) |
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IC50 | 70±n/a nM |
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Citation | He, S; Ye, Z; Dobbelaar, PH; Sebhat, IK; Guo, L; Liu, J; Jian, T; Lai, Y; Franklin, CL; Bakshi, RK; Dellureficio, JP; Hong, Q; Weinberg, DH; Macneil, T; Tang, R; Strack, AM; Tamvakopoulos, C; Peng, Q; Miller, RR; Stearns, RA; Chen, HY; Chen, AS; Fong, TM; Wyvratt, MJ; Nargund, RP Spiroindane based amides as potent and selective MC4R agonists for the treatment of obesity. Bioorg Med Chem Lett20:4399-405 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Melanocortin receptor 4 |
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Name: | Melanocortin receptor 4 |
Synonyms: | MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R) |
Type: | Enzyme |
Mol. Mass.: | 36949.50 |
Organism: | Homo sapiens (Human) |
Description: | P32245 |
Residue: | 332 |
Sequence: | MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY
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BDBM50329962 |
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n/a |
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Name | BDBM50329962 |
Synonyms: | CHEMBL404696 | N-((S)-1-(2-(1-((3R,4S)-1-tert-butyl-3-(2,4-difluorophenyl)pyrrolidine-4-carbonyl)piperidin-4-yl)-5-chlorophenyl)propyl)acetamide | N-((S)-1-(2-(1-((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl)piperidin-4-yl)-5-chlorophenyl)propyl)acetamide |
Type | Small organic molecule |
Emp. Form. | C31H40ClF2N3O2 |
Mol. Mass. | 560.118 |
SMILES | CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(CC1)C(=O)[C@@H]1CN(C[C@H]1c1ccc(F)cc1F)C(C)(C)C |
Structure |
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