| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Glutamate receptor ionotropic, kainate 2 |
|---|
| Ligand | BDBM50349981 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_761798 (CHEMBL1817065) |
|---|
| Ki | >1000000±n/a nM |
|---|
| Citation |  Venskutonyte, R; Butini, S; Coccone, SS; Gemma, S; Brindisi, M; Kumar, V; Guarino, E; Maramai, S; Valenti, S; Amir, A; Valadés, EA; Frydenvang, K; Kastrup, JS; Novellino, E; Campiani, G; Pickering, DS Selective kainate receptor (GluK1) ligands structurally based upon 1H-cyclopentapyrimidin-2,4(1H,3H)-dione: synthesis, molecular modeling, and pharmacological and biostructural characterization. J Med Chem54:4793-805 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Glutamate receptor ionotropic, kainate 2 |
|---|
| Name: | Glutamate receptor ionotropic, kainate 2 |
|---|
| Synonyms: | GRIK2_RAT | Glur6 | Glutamate receptor ionotropic kainate 2 | Grik2 | Ionotropic glutamate receptor kainate 2/5 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 102478.61 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_936439 |
|---|
| Residue: | 908 |
|---|
| Sequence: | MKIISPVLSNLVFSRSIKVLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFA
VNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQS
ICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDST
GLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILK
QALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMER
LQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFM
SLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGK
PANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEI
RLVEDGKYGAQDDVNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISI
LYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSD
VVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLT
VERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKS
NEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITI
AILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVG
EFLYKSKKNAQLEKRSFCSAMVEELRMSLKCQRRLKHKPQAPVIVKTEEVINMHTFNDRR
LPGKETMA
|
|
|
|---|
| BDBM50349981 |
|---|
| n/a |
|---|
| Name | BDBM50349981 |
|---|
| Synonyms: | CHEMBL1812598 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C9H9N3O4S |
|---|
| Mol. Mass. | 255.25 |
|---|
| SMILES | N[C@@H](Cn1c2sccc2c(=O)[nH]c1=O)C(O)=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
