Reaction Details | |||
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Target | Acetyl-CoA carboxylase 2 | ||
Ligand | BDBM50350751 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_762997 (CHEMBL1820814) | ||
IC50 | 1400±n/a nM | ||
Citation | Bengtsson, C; Blaho, S; Saitton, DB; Brickmann, K; Broddefalk, J; Davidsson, O; Drmota, T; Folmer, R; Hallberg, K; Hallén, S; Hovland, R; Isin, E; Johannesson, P; Kull, B; Larsson, LO; Löfgren, L; Nilsson, KE; Noeske, T; Oakes, N; Plowright, AT; Schnecke, V; Ståhlberg, P; Sörme, P; Wan, H; Wellner, E; Oster, L Design of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 showing reduction of hepatic malonyl-CoA levels in vivo in obese Zucker rats. Bioorg Med Chem19:3039-53 (2011) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Acetyl-CoA carboxylase 2 | |||
Name: | Acetyl-CoA carboxylase 2 | ||
Synonyms: | ACACB | ACACB_HUMAN | ACC-beta | ACC2 | ACCB | Acetyl-CoA carboxylase | Acetyl-CoA carboxylase 2 | Acetyl-CoA carboxylase 2 (ACC) | Acetyl-CoA carboxylase 2 (ACC2) | ||
Type: | Protein | ||
Mol. Mass.: | 276535.21 | ||
Organism: | Homo sapiens (Human) | ||
Description: | O00763 | ||
Residue: | 2458 | ||
Sequence: |
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BDBM50350751 | |||
n/a | |||
Name | BDBM50350751 | ||
Synonyms: | CHEMBL1818301 | ||
Type | Small organic molecule | ||
Emp. Form. | C30H45N5O3 | ||
Mol. Mass. | 523.71 | ||
SMILES | CCOC(=O)NC[C@H]1CC[C@H](CNC(=O)c2cc(nc3ccccc23)N2CCC(CCN(C)C)CC2)CC1 |r,wU:7.6,wD:10.10,(-8.16,2.85,;-6.83,3.62,;-5.49,2.85,;-4.16,3.62,;-4.16,5.16,;-2.83,2.85,;-2.82,1.31,;-1.49,.55,;-.15,1.32,;1.18,.55,;1.19,-.99,;2.52,-1.76,;2.53,-3.3,;3.87,-4.06,;5.2,-3.28,;3.88,-5.6,;5.21,-6.36,;5.22,-7.91,;3.89,-8.68,;2.55,-7.91,;1.22,-8.69,;-.11,-7.92,;-.11,-6.38,;1.22,-5.61,;2.55,-6.37,;6.56,-8.67,;6.55,-10.21,;7.88,-10.97,;9.22,-10.2,;10.55,-10.97,;10.55,-12.51,;11.88,-13.28,;11.88,-14.82,;13.22,-12.51,;9.22,-8.66,;7.88,-7.89,;-.15,-1.77,;-1.48,-1,)| | ||
Structure |