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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Acetyl-CoA carboxylase 2 | ||
| Ligand | BDBM50350754 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_762997 (CHEMBL1820814) | ||
| IC50 | 1700±n/a nM | ||
| Citation |  Bengtsson, C; Blaho, S; Saitton, DB; Brickmann, K; Broddefalk, J; Davidsson, O; Drmota, T; Folmer, R; Hallberg, K; Hallén, S; Hovland, R; Isin, E; Johannesson, P; Kull, B; Larsson, LO; Löfgren, L; Nilsson, KE; Noeske, T; Oakes, N; Plowright, AT; Schnecke, V; Ståhlberg, P; Sörme, P; Wan, H; Wellner, E; Oster, L Design of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 showing reduction of hepatic malonyl-CoA levels in vivo in obese Zucker rats. Bioorg Med Chem19:3039-53 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Acetyl-CoA carboxylase 2 | |||
| Name: | Acetyl-CoA carboxylase 2 | ||
| Synonyms: | ACACB | ACACB_HUMAN | ACC-beta | ACC2 | ACCB | Acetyl-CoA carboxylase | Acetyl-CoA carboxylase 2 | Acetyl-CoA carboxylase 2 (ACC) | Acetyl-CoA carboxylase 2 (ACC2) | ||
| Type: | Protein | ||
| Mol. Mass.: | 276535.21 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O00763 | ||
| Residue: | 2458 | ||
| Sequence: |
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| BDBM50350754 | |||
| n/a | |||
| Name | BDBM50350754 | ||
| Synonyms: | CHEMBL1817676 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C32H49N5O3 | ||
| Mol. Mass. | 551.7632 | ||
| SMILES | CN(C)CCC1CCN(CC1)c1cc(C(=O)NC[C@H]2CC[C@H](COC(=O)NC(C)(C)C)CC2)c2ccccc2n1 |r,wU:21.22,wD:18.18,(13.42,-34.17,;13.42,-32.63,;14.76,-31.86,;12.09,-31.86,;12.09,-30.32,;10.76,-29.55,;9.42,-30.32,;8.09,-29.56,;8.1,-28.02,;9.42,-27.24,;10.75,-28.01,;6.76,-27.26,;6.75,-25.71,;5.42,-24.95,;5.41,-23.41,;6.74,-22.63,;4.07,-22.65,;4.06,-21.11,;2.73,-20.34,;2.72,-18.8,;1.39,-18.04,;.05,-18.81,;-1.28,-18.04,;-1.29,-16.5,;-2.62,-15.73,;-2.62,-14.19,;-3.95,-16.5,;-5.29,-15.73,;-5.29,-14.19,;-6.62,-16.5,;-6.62,-14.96,;.06,-20.35,;1.39,-21.12,;4.09,-25.72,;2.76,-24.96,;1.43,-25.73,;1.43,-27.27,;2.76,-28.04,;4.09,-27.26,;5.43,-28.03,)| | ||
| Structure | 
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