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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Acetyl-CoA carboxylase | ||
| Ligand | BDBM50350747 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_763012 (CHEMBL1820829) | ||
| IC50 | 190±n/a nM | ||
| Citation |  Bengtsson, C; Blaho, S; Saitton, DB; Brickmann, K; Broddefalk, J; Davidsson, O; Drmota, T; Folmer, R; Hallberg, K; Hallén, S; Hovland, R; Isin, E; Johannesson, P; Kull, B; Larsson, LO; Löfgren, L; Nilsson, KE; Noeske, T; Oakes, N; Plowright, AT; Schnecke, V; Ståhlberg, P; Sörme, P; Wan, H; Wellner, E; Oster, L Design of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 showing reduction of hepatic malonyl-CoA levels in vivo in obese Zucker rats. Bioorg Med Chem19:3039-53 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Acetyl-CoA carboxylase | |||
| Name: | Acetyl-CoA carboxylase | ||
| Synonyms: | Acetyl-CoA carboxylase 2 (ACC2) | Acetyl-Coenzyme A carboxylase 2 | ||
| Type: | Protein | ||
| Mol. Mass.: | 276278.59 | ||
| Organism: | Rattus norvegicus (Rat) | ||
| Description: | n/a | ||
| Residue: | 2455 | ||
| Sequence: |
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| BDBM50350747 | |||
| n/a | |||
| Name | BDBM50350747 | ||
| Synonyms: | CHEMBL1818296 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C32H49N5O3 | ||
| Mol. Mass. | 551.7632 | ||
| SMILES | CN(C)CCC1CCN(CC1)c1cc(C(=O)NC[C@H]2CC[C@H](CNC(=O)OC(C)(C)C)CC2)c2ccccc2n1 |r,wU:21.22,wD:18.18,(43.4,-32.84,;43.39,-31.3,;44.72,-30.52,;42.06,-30.53,;42.05,-28.99,;40.71,-28.23,;39.38,-29,;38.05,-28.23,;38.04,-26.69,;39.37,-25.92,;40.71,-26.68,;36.72,-25.92,;36.71,-24.39,;35.38,-23.63,;35.38,-22.09,;36.72,-21.32,;34.05,-21.31,;34.05,-19.77,;32.72,-19,;32.72,-17.46,;31.39,-16.68,;30.06,-17.46,;28.73,-16.7,;28.72,-15.15,;27.38,-14.39,;27.38,-12.85,;26.05,-15.16,;24.72,-14.4,;23.38,-15.17,;24.71,-12.86,;23.38,-13.62,;30.06,-19,;31.39,-19.77,;34.05,-24.39,;32.73,-23.62,;31.4,-24.38,;31.4,-25.92,;32.72,-26.69,;34.04,-25.93,;35.38,-26.7,)| | ||
| Structure | 
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