Ki Summary

Reaction Details

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Target

Neuropeptide Y receptor type 2

Ligand

BDBM50354071

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_770874 (CHEMBL1837822)

IC50

>1000±n/a nM

Citation

Packiarajan, M; Marzabadi, MR; Desai, M; Lu, Y; Noble, SA; Wong, WC; Jubian, V; Chandrasena, G; Wolinsky, TD; Zhong, H; Walker, MW; Wiborg, O; Andersen, K Discovery of Lu AA33810: a highly selective and potent NPY5 antagonist with in vivo efficacy in a model of mood disorder. Bioorg Med Chem Lett21:5436-41 (2011) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Neuropeptide Y receptor type 2

Name:

Neuropeptide Y receptor type 2

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

42734.65

Organism:

Homo sapiens (Human)

Description:

NPY-Y2 NPY2R HUMAN::P49146

Residue:

381

Sequence:

MGPIGAEADENQTVEEMKVEQYGPQTTPRGELVPDPEPELIDSTKLIEVQVVLILAYCSI
ILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGP
VLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKRISFLIIGLAWGISALLA
SPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYT
RIWSKLKNHVSPGAANDHYHQRRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVLDL
KEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSEVSVTFKAK
KNLEVRKNSGPNDSFTEATNV

BDBM50354071

n/a

Name

BDBM50354071

Synonyms:

CHEMBL1836318

Type

Small organic molecule

Emp. Form.

C20H27N3O2S3

Mol. Mass.

437.642

SMILES

CCS(=O)(=O)NC[C@H]1CC[C@@H](CC1)Nc1nc-2c(CCSc3ccccc-23)s1 |r,wU:7.6,wD:10.13,(6.6,-30,;5.27,-29.21,;5.29,-27.67,;6.84,-27.69,;6.08,-26.34,;3.97,-26.88,;3.99,-25.34,;2.66,-24.55,;1.31,-25.3,;-.01,-24.52,;.01,-22.97,;1.35,-22.21,;2.68,-23,;-1.32,-22.19,;-2.66,-22.95,;-4.03,-22.33,;-5.04,-23.43,;-4.3,-24.74,;-4.92,-26.21,;-6.42,-26.6,;-7.64,-25.66,;-7.67,-24.07,;-9.06,-23.55,;-9.31,-22.09,;-8.16,-21.14,;-6.77,-21.66,;-6.52,-23.12,;-2.83,-24.44,)|

Structure