| Reaction Details |
|---|
 | Report a problem with these data |
| Target | SNF-related serine/threonine-protein kinase |
|---|
| Ligand | BDBM50355501 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_774232 (CHEMBL1908449) |
|---|
| Kd | >10000±n/a nM |
|---|
| Citation |  Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol29:1046-51 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| SNF-related serine/threonine-protein kinase |
|---|
| Name: | SNF-related serine/threonine-protein kinase |
|---|
| Synonyms: | KIAA0096 | SNF1-related kinase | SNFRK | SNRK | SNRK_HUMAN |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 84281.84 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_774232 |
|---|
| Residue: | 765 |
|---|
| Sequence: | MAGFKRGYDGKIAGLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHL
FQEVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYF
AQIVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAY
SAPEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSK
ECKDLITRMLQRDPKRRASLEEIENHPWLQGVDPSPATKYNIPLVSYKNLSEEEHNSIIQ
RMVLGDIADRDAIVEALETNRYNHITATYFLLAERILREKQEKEIQTRSASPSNIKAQFR
QSWPTKIDVPQDLEDDLTATPLSHATVPQSPARAADSVLNGHRSKGLCDSAKKDDLPELA
GPALSTVPPASLKPTASGRKCLFRVEEDEEEDEEDKKPMSLSTQVVLRRKPSVTNRLTSR
KSAPVLNQIFEEGESDDEFDMDENLPPKLSRLKMNIASPGTVHKRYHRRKSQGRGSSCSS
SETSDDDSESRRRLDKDSGFTYSWHRRDSSEGPPGSEGDGGGQSKPSNASGGVDKASPSE
NNAGGGSPSSGSGGNPTNTSGTTRRCAGPSNSMQLASRSAGELVESLKLMSLCLGSQLHG
STKYIIDPQNGLSFSSVKVQEKSTWKMCISSTGNAGQVPAVGGIKFFSDHMADTTTELER
IKSKNLKNNVLQLPLCEKTISVNIQRNPKEGLLCASSPASCCHVI
|
|
|
|---|
| BDBM50355501 |
|---|
| n/a |
|---|
| Name | BDBM50355501 |
|---|
| Synonyms: | INCB-018424 | RUXOLITINIB | RUXOLITINIB PHOSPHATE | US10112907, Example 00016 | US10766894, Compound TABLE 1.1 | US10875847, Compound JAKAFI | US11203595, TABLE 1.1 | US11279703, TABLE 6.147 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H18N6 |
|---|
| Mol. Mass. | 306.365 |
|---|
| SMILES | N#CC[C@H](C1CCCC1)n1cc(cn1)-c1ncnc2[nH]ccc12 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
