Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aurora kinase A (Homo sapiens (Human)) | BDBM81552 (Benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one, 1...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School | Assay Description In vitro biochemical assays were performed in parallel to determine the most potent tool compound. | Chem Biol 18: 868-79 (2011) Article DOI: 10.1016/j.chembiol.2011.05.010 BindingDB Entry DOI: 10.7270/Q2HD7T57 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aurora kinase B (Homo sapiens (Human)) | BDBM81552 (Benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one, 1...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School | Assay Description In vitro biochemical assays were performed in parallel to determine the most potent tool compound. | Chem Biol 18: 868-79 (2011) Article DOI: 10.1016/j.chembiol.2011.05.010 BindingDB Entry DOI: 10.7270/Q2HD7T57 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aurora kinase C (Homo sapiens (Human)) | BDBM81552 (Benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one, 1...) | PDB NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School | Assay Description In vitro biochemical assays were performed in parallel to determine the most potent tool compound. | Chem Biol 18: 868-79 (2011) Article DOI: 10.1016/j.chembiol.2011.05.010 BindingDB Entry DOI: 10.7270/Q2HD7T57 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human)) | BDBM81550 (Furan thiazolidinediones, A47) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 49 | 40 | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School | Assay Description In vitro biochemical assays were performed in parallel to determine the most potent tool compound. | Chem Biol 18: 868-79 (2011) Article DOI: 10.1016/j.chembiol.2011.05.010 BindingDB Entry DOI: 10.7270/Q2HD7T57 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human)) | BDBM81550 (Furan thiazolidinediones, A47) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 49 | 23 | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School | Assay Description In vitro biochemical assays were performed in parallel to determine the most potent tool compound. | Chem Biol 18: 868-79 (2011) Article DOI: 10.1016/j.chembiol.2011.05.010 BindingDB Entry DOI: 10.7270/Q2HD7T57 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Homeodomain-interacting protein kinase 2 (Homo sapiens (Human)) | BDBM81551 (Furan thiazolidinediones, A64) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 74 | 9.5 | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School | Assay Description In vitro biochemical assays were performed in parallel to determine the most potent tool compound. | Chem Biol 18: 868-79 (2011) Article DOI: 10.1016/j.chembiol.2011.05.010 BindingDB Entry DOI: 10.7270/Q2HD7T57 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dual specificity protein kinase TTK (Homo sapiens (Human)) | BDBM36486 (9-Cyclopentyl-2-(2-ethoxy-4-(4-hydroxypiperidin-1-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 145 | 26 | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School | Assay Description In vitro biochemical assays were performed in parallel to determine the most potent tool compound. | Chem Biol 18: 868-79 (2011) Article DOI: 10.1016/j.chembiol.2011.05.010 BindingDB Entry DOI: 10.7270/Q2HD7T57 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [201-500] (Homo sapiens (Human)) | BDBM13530 (4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank PDB Article PubMed | n/a | n/a | n/a | 2 | n/a | n/a | n/a | 7.4 | 25 |
Ambit, Inc. | Assay Description Competition binding assay was used to measure the interaction between the phage-tagged kinase, immobilized competitive ligand, and unlinked test comp... | Proc Natl Acad Sci U S A 102: 11011-6 (2005) Article DOI: 10.1073/pnas.0504952102 BindingDB Entry DOI: 10.7270/Q29C6VNB | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Tyrosine-protein kinase ABL1 [201-500,Q252H] (Homo sapiens (Human)) | BDBM13530 (4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | 20 | n/a | n/a | n/a | 7.4 | 25 |
Ambit, Inc. | Assay Description Competition binding assay was used to measure the interaction between the phage-tagged kinase, immobilized competitive ligand, and unlinked test comp... | Proc Natl Acad Sci U S A 102: 11011-6 (2005) Article DOI: 10.1073/pnas.0504952102 BindingDB Entry DOI: 10.7270/Q29C6VNB | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Tyrosine-protein kinase ABL1 [201-500,Y253F] (Homo sapiens (Human)) | BDBM13530 (4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | 40 | n/a | n/a | n/a | 7.4 | 25 |
Ambit, Inc. | Assay Description Competition binding assay was used to measure the interaction between the phage-tagged kinase, immobilized competitive ligand, and unlinked test comp... | Proc Natl Acad Sci U S A 102: 11011-6 (2005) Article DOI: 10.1073/pnas.0504952102 BindingDB Entry DOI: 10.7270/Q29C6VNB | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Tyrosine-protein kinase ABL1 [201-500,E255K] (Homo sapiens (Human)) | BDBM13530 (4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | 100 | n/a | n/a | n/a | 7.4 | 25 |
Ambit, Inc. | Assay Description Competition binding assay was used to measure the interaction between the phage-tagged kinase, immobilized competitive ligand, and unlinked test comp... | Proc Natl Acad Sci U S A 102: 11011-6 (2005) Article DOI: 10.1073/pnas.0504952102 BindingDB Entry DOI: 10.7270/Q29C6VNB | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Tyrosine-protein kinase ABL1 [201-500,M351T] (Homo sapiens (Human)) | BDBM13530 (4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | 10 | n/a | n/a | n/a | 7.4 | 25 |
Ambit, Inc. | Assay Description Competition binding assay was used to measure the interaction between the phage-tagged kinase, immobilized competitive ligand, and unlinked test comp... | Proc Natl Acad Sci U S A 102: 11011-6 (2005) Article DOI: 10.1073/pnas.0504952102 BindingDB Entry DOI: 10.7270/Q29C6VNB | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Tyrosine-protein kinase ABL1 [201-500] (Homo sapiens (Human)) | BDBM13216 (BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank PDB Article PubMed | n/a | n/a | n/a | 0.5 | n/a | n/a | n/a | 7.4 | 25 |
Ambit, Inc. | Assay Description Competition binding assay was used to measure the interaction between the phage-tagged kinase, immobilized competitive ligand, and unlinked test comp... | Proc Natl Acad Sci U S A 102: 11011-6 (2005) Article DOI: 10.1073/pnas.0504952102 BindingDB Entry DOI: 10.7270/Q29C6VNB | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Tyrosine-protein kinase ABL1 [201-500,Q252H] (Homo sapiens (Human)) | BDBM13216 (BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | 1 | n/a | n/a | n/a | 7.4 | 25 |
Ambit, Inc. | Assay Description Competition binding assay was used to measure the interaction between the phage-tagged kinase, immobilized competitive ligand, and unlinked test comp... | Proc Natl Acad Sci U S A 102: 11011-6 (2005) Article DOI: 10.1073/pnas.0504952102 BindingDB Entry DOI: 10.7270/Q29C6VNB | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Tyrosine-protein kinase ABL1 [201-500,Y253F] (Homo sapiens (Human)) | BDBM13216 (BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | 1 | n/a | n/a | n/a | 7.4 | 25 |
Ambit, Inc. | Assay Description Competition binding assay was used to measure the interaction between the phage-tagged kinase, immobilized competitive ligand, and unlinked test comp... | Proc Natl Acad Sci U S A 102: 11011-6 (2005) Article DOI: 10.1073/pnas.0504952102 BindingDB Entry DOI: 10.7270/Q29C6VNB | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Tyrosine-protein kinase ABL1 [201-500,E255K] (Homo sapiens (Human)) | BDBM13216 (BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | 2 | n/a | n/a | n/a | 7.4 | 25 |
Ambit, Inc. | Assay Description Competition binding assay was used to measure the interaction between the phage-tagged kinase, immobilized competitive ligand, and unlinked test comp... | Proc Natl Acad Sci U S A 102: 11011-6 (2005) Article DOI: 10.1073/pnas.0504952102 BindingDB Entry DOI: 10.7270/Q29C6VNB | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Tyrosine-protein kinase ABL1 [201-500,M351T] (Homo sapiens (Human)) | BDBM13216 (BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | 0.700 | n/a | n/a | n/a | 7.4 | 25 |
Ambit, Inc. | Assay Description Competition binding assay was used to measure the interaction between the phage-tagged kinase, immobilized competitive ligand, and unlinked test comp... | Proc Natl Acad Sci U S A 102: 11011-6 (2005) Article DOI: 10.1073/pnas.0504952102 BindingDB Entry DOI: 10.7270/Q29C6VNB | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Tyrosine-protein kinase ABL1 [201-500,F359V] (Homo sapiens (Human)) | BDBM13216 (BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | 0.300 | n/a | n/a | n/a | 7.4 | 25 |
Ambit, Inc. | Assay Description Competition binding assay was used to measure the interaction between the phage-tagged kinase, immobilized competitive ligand, and unlinked test comp... | Proc Natl Acad Sci U S A 102: 11011-6 (2005) Article DOI: 10.1073/pnas.0504952102 BindingDB Entry DOI: 10.7270/Q29C6VNB | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Tyrosine-protein kinase ABL1 [201-500,H396P] (Homo sapiens (Human)) | BDBM13530 (4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a |
Ambit, Inc. | Assay Description Competition binding assay was used to measure the interaction between the phage-tagged kinase, immobilized competitive ligand, and unlinked test comp... | Proc Natl Acad Sci U S A 102: 11011-6 (2005) Article DOI: 10.1073/pnas.0504952102 BindingDB Entry DOI: 10.7270/Q29C6VNB | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Tyrosine-protein kinase ABL1 [201-500,T315I] (Homo sapiens (Human)) | BDBM13530 (4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | n/a |
Ambit, Inc. | Assay Description Competition binding assay was used to measure the interaction between the phage-tagged kinase, immobilized competitive ligand, and unlinked test comp... | Proc Natl Acad Sci U S A 102: 11011-6 (2005) Article DOI: 10.1073/pnas.0504952102 BindingDB Entry DOI: 10.7270/Q29C6VNB | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Mast/stem cell growth factor receptor Kit [N822K] (Homo sapiens (Human)) | BDBM13530 (4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a |
Ambit, Inc. | Assay Description Competition binding assay was used to measure the interaction between the phage-tagged kinase, immobilized competitive ligand, and unlinked test comp... | Proc Natl Acad Sci U S A 102: 11011-6 (2005) Article DOI: 10.1073/pnas.0504952102 BindingDB Entry DOI: 10.7270/Q29C6VNB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mast/stem cell growth factor receptor Kit [V559D] (Homo sapiens (Human)) | BDBM13530 (4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a |
Ambit, Inc. | Assay Description Competition binding assay was used to measure the interaction between the phage-tagged kinase, immobilized competitive ligand, and unlinked test comp... | Proc Natl Acad Sci U S A 102: 11011-6 (2005) Article DOI: 10.1073/pnas.0504952102 BindingDB Entry DOI: 10.7270/Q29C6VNB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mast/stem cell growth factor receptor Kit [V559D,T670I] (Homo sapiens (Human)) | BDBM13530 (4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a |
Ambit, Inc. | Assay Description Competition binding assay was used to measure the interaction between the phage-tagged kinase, immobilized competitive ligand, and unlinked test comp... | Proc Natl Acad Sci U S A 102: 11011-6 (2005) Article DOI: 10.1073/pnas.0504952102 BindingDB Entry DOI: 10.7270/Q29C6VNB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [201-500,H396P] (Homo sapiens (Human)) | BDBM13216 (BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a |
Ambit, Inc. | Assay Description Competition binding assay was used to measure the interaction between the phage-tagged kinase, immobilized competitive ligand, and unlinked test comp... | Proc Natl Acad Sci U S A 102: 11011-6 (2005) Article DOI: 10.1073/pnas.0504952102 BindingDB Entry DOI: 10.7270/Q29C6VNB | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Tyrosine-protein kinase ABL1 [201-500,T315N] (Homo sapiens (Human)) | BDBM13216 (BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a |
Ambit, Inc. | Assay Description Competition binding assay was used to measure the interaction between the phage-tagged kinase, immobilized competitive ligand, and unlinked test comp... | Proc Natl Acad Sci U S A 102: 11011-6 (2005) Article DOI: 10.1073/pnas.0504952102 BindingDB Entry DOI: 10.7270/Q29C6VNB | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Mast/stem cell growth factor receptor Kit [N822K] (Homo sapiens (Human)) | BDBM13216 (BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a |
Ambit, Inc. | Assay Description Competition binding assay was used to measure the interaction between the phage-tagged kinase, immobilized competitive ligand, and unlinked test comp... | Proc Natl Acad Sci U S A 102: 11011-6 (2005) Article DOI: 10.1073/pnas.0504952102 BindingDB Entry DOI: 10.7270/Q29C6VNB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mast/stem cell growth factor receptor Kit [V559D] (Homo sapiens (Human)) | BDBM13216 (BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a |
Ambit, Inc. | Assay Description Competition binding assay was used to measure the interaction between the phage-tagged kinase, immobilized competitive ligand, and unlinked test comp... | Proc Natl Acad Sci U S A 102: 11011-6 (2005) Article DOI: 10.1073/pnas.0504952102 BindingDB Entry DOI: 10.7270/Q29C6VNB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mast/stem cell growth factor receptor Kit [V559D,T670I] (Homo sapiens (Human)) | BDBM13216 (BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a |
Ambit, Inc. | Assay Description Competition binding assay was used to measure the interaction between the phage-tagged kinase, immobilized competitive ligand, and unlinked test comp... | Proc Natl Acad Sci U S A 102: 11011-6 (2005) Article DOI: 10.1073/pnas.0504952102 BindingDB Entry DOI: 10.7270/Q29C6VNB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [201-500] (Homo sapiens (Human)) | BDBM6572 (6-(2,6-dichlorophenyl)-2-[(4-fluoro-3-methylphenyl...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a |
Ambit, Inc. | Assay Description Competition binding assay was used to measure the interaction between the phage-tagged kinase, immobilized competitive ligand, and unlinked test comp... | Proc Natl Acad Sci U S A 102: 11011-6 (2005) Article DOI: 10.1073/pnas.0504952102 BindingDB Entry DOI: 10.7270/Q29C6VNB | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Tyrosine-protein kinase ABL1 [201-500,Q252H] (Homo sapiens (Human)) | BDBM6572 (6-(2,6-dichlorophenyl)-2-[(4-fluoro-3-methylphenyl...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a |
Ambit, Inc. | Assay Description Competition binding assay was used to measure the interaction between the phage-tagged kinase, immobilized competitive ligand, and unlinked test comp... | Proc Natl Acad Sci U S A 102: 11011-6 (2005) Article DOI: 10.1073/pnas.0504952102 BindingDB Entry DOI: 10.7270/Q29C6VNB | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Tyrosine-protein kinase ABL1 [201-500,Y253F] (Homo sapiens (Human)) | BDBM6572 (6-(2,6-dichlorophenyl)-2-[(4-fluoro-3-methylphenyl...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a |
Ambit, Inc. | Assay Description Competition binding assay was used to measure the interaction between the phage-tagged kinase, immobilized competitive ligand, and unlinked test comp... | Proc Natl Acad Sci U S A 102: 11011-6 (2005) Article DOI: 10.1073/pnas.0504952102 BindingDB Entry DOI: 10.7270/Q29C6VNB | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Tyrosine-protein kinase ABL1 [201-500,E255K] (Homo sapiens (Human)) | BDBM6572 (6-(2,6-dichlorophenyl)-2-[(4-fluoro-3-methylphenyl...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a |
Ambit, Inc. | Assay Description Competition binding assay was used to measure the interaction between the phage-tagged kinase, immobilized competitive ligand, and unlinked test comp... | Proc Natl Acad Sci U S A 102: 11011-6 (2005) Article DOI: 10.1073/pnas.0504952102 BindingDB Entry DOI: 10.7270/Q29C6VNB | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Tyrosine-protein kinase ABL1 [201-500,M351T] (Homo sapiens (Human)) | BDBM6572 (6-(2,6-dichlorophenyl)-2-[(4-fluoro-3-methylphenyl...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a |
Ambit, Inc. | Assay Description Competition binding assay was used to measure the interaction between the phage-tagged kinase, immobilized competitive ligand, and unlinked test comp... | Proc Natl Acad Sci U S A 102: 11011-6 (2005) Article DOI: 10.1073/pnas.0504952102 BindingDB Entry DOI: 10.7270/Q29C6VNB | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Tyrosine-protein kinase ABL1 [201-500,F359V] (Homo sapiens (Human)) | BDBM6572 (6-(2,6-dichlorophenyl)-2-[(4-fluoro-3-methylphenyl...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a |
Ambit, Inc. | Assay Description Competition binding assay was used to measure the interaction between the phage-tagged kinase, immobilized competitive ligand, and unlinked test comp... | Proc Natl Acad Sci U S A 102: 11011-6 (2005) Article DOI: 10.1073/pnas.0504952102 BindingDB Entry DOI: 10.7270/Q29C6VNB | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Tyrosine-protein kinase ABL1 [201-500] (Homo sapiens (Human)) | BDBM13533 (1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a |
Ambit, Inc. | Assay Description Competition binding assay was used to measure the interaction between the phage-tagged kinase, immobilized competitive ligand, and unlinked test comp... | Proc Natl Acad Sci U S A 102: 11011-6 (2005) Article DOI: 10.1073/pnas.0504952102 BindingDB Entry DOI: 10.7270/Q29C6VNB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [201-500,Q252H] (Homo sapiens (Human)) | BDBM13533 (1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a |
Ambit, Inc. | Assay Description Competition binding assay was used to measure the interaction between the phage-tagged kinase, immobilized competitive ligand, and unlinked test comp... | Proc Natl Acad Sci U S A 102: 11011-6 (2005) Article DOI: 10.1073/pnas.0504952102 BindingDB Entry DOI: 10.7270/Q29C6VNB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [201-500,Y253F] (Homo sapiens (Human)) | BDBM13533 (1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a |
Ambit, Inc. | Assay Description Competition binding assay was used to measure the interaction between the phage-tagged kinase, immobilized competitive ligand, and unlinked test comp... | Proc Natl Acad Sci U S A 102: 11011-6 (2005) Article DOI: 10.1073/pnas.0504952102 BindingDB Entry DOI: 10.7270/Q29C6VNB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [201-500,E255K] (Homo sapiens (Human)) | BDBM13533 (1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a |
Ambit, Inc. | Assay Description Competition binding assay was used to measure the interaction between the phage-tagged kinase, immobilized competitive ligand, and unlinked test comp... | Proc Natl Acad Sci U S A 102: 11011-6 (2005) Article DOI: 10.1073/pnas.0504952102 BindingDB Entry DOI: 10.7270/Q29C6VNB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [201-500,F359V] (Homo sapiens (Human)) | BDBM13533 (1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 8.00E+3 | n/a | n/a | n/a | n/a | n/a |
Ambit, Inc. | Assay Description Competition binding assay was used to measure the interaction between the phage-tagged kinase, immobilized competitive ligand, and unlinked test comp... | Proc Natl Acad Sci U S A 102: 11011-6 (2005) Article DOI: 10.1073/pnas.0504952102 BindingDB Entry DOI: 10.7270/Q29C6VNB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [201-500] (Homo sapiens (Human)) | BDBM13534 (CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a |
Ambit, Inc. | Assay Description Competition binding assay was used to measure the interaction between the phage-tagged kinase, immobilized competitive ligand, and unlinked test comp... | Proc Natl Acad Sci U S A 102: 11011-6 (2005) Article DOI: 10.1073/pnas.0504952102 BindingDB Entry DOI: 10.7270/Q29C6VNB | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Tyrosine-protein kinase ABL1 [201-500,Q252H] (Homo sapiens (Human)) | BDBM13534 (CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a |
Ambit, Inc. | Assay Description Competition binding assay was used to measure the interaction between the phage-tagged kinase, immobilized competitive ligand, and unlinked test comp... | Proc Natl Acad Sci U S A 102: 11011-6 (2005) Article DOI: 10.1073/pnas.0504952102 BindingDB Entry DOI: 10.7270/Q29C6VNB | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Tyrosine-protein kinase ABL1 [201-500,Y253F] (Homo sapiens (Human)) | BDBM13534 (CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a |
Ambit, Inc. | Assay Description Competition binding assay was used to measure the interaction between the phage-tagged kinase, immobilized competitive ligand, and unlinked test comp... | Proc Natl Acad Sci U S A 102: 11011-6 (2005) Article DOI: 10.1073/pnas.0504952102 BindingDB Entry DOI: 10.7270/Q29C6VNB | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Tyrosine-protein kinase ABL1 [201-500,E255K] (Homo sapiens (Human)) | BDBM13534 (CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a |
Ambit, Inc. | Assay Description Competition binding assay was used to measure the interaction between the phage-tagged kinase, immobilized competitive ligand, and unlinked test comp... | Proc Natl Acad Sci U S A 102: 11011-6 (2005) Article DOI: 10.1073/pnas.0504952102 BindingDB Entry DOI: 10.7270/Q29C6VNB | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Tyrosine-protein kinase ABL1 [201-500,M351T] (Homo sapiens (Human)) | BDBM13534 (CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a |
Ambit, Inc. | Assay Description Competition binding assay was used to measure the interaction between the phage-tagged kinase, immobilized competitive ligand, and unlinked test comp... | Proc Natl Acad Sci U S A 102: 11011-6 (2005) Article DOI: 10.1073/pnas.0504952102 BindingDB Entry DOI: 10.7270/Q29C6VNB | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Tyrosine-protein kinase ABL1 [201-500,T315I] (Homo sapiens (Human)) | BDBM6572 (6-(2,6-dichlorophenyl)-2-[(4-fluoro-3-methylphenyl...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a |
Ambit, Inc. | Assay Description Competition binding assay was used to measure the interaction between the phage-tagged kinase, immobilized competitive ligand, and unlinked test comp... | Proc Natl Acad Sci U S A 102: 11011-6 (2005) Article DOI: 10.1073/pnas.0504952102 BindingDB Entry DOI: 10.7270/Q29C6VNB | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Tyrosine-protein kinase ABL1 [201-500,T315N] (Homo sapiens (Human)) | BDBM6572 (6-(2,6-dichlorophenyl)-2-[(4-fluoro-3-methylphenyl...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a |
Ambit, Inc. | Assay Description Competition binding assay was used to measure the interaction between the phage-tagged kinase, immobilized competitive ligand, and unlinked test comp... | Proc Natl Acad Sci U S A 102: 11011-6 (2005) Article DOI: 10.1073/pnas.0504952102 BindingDB Entry DOI: 10.7270/Q29C6VNB | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Mast/stem cell growth factor receptor Kit [N822K] (Homo sapiens (Human)) | BDBM6572 (6-(2,6-dichlorophenyl)-2-[(4-fluoro-3-methylphenyl...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a |
Ambit, Inc. | Assay Description Competition binding assay was used to measure the interaction between the phage-tagged kinase, immobilized competitive ligand, and unlinked test comp... | Proc Natl Acad Sci U S A 102: 11011-6 (2005) Article DOI: 10.1073/pnas.0504952102 BindingDB Entry DOI: 10.7270/Q29C6VNB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mast/stem cell growth factor receptor Kit [V559D,T670I] (Homo sapiens (Human)) | BDBM6572 (6-(2,6-dichlorophenyl)-2-[(4-fluoro-3-methylphenyl...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a |
Ambit, Inc. | Assay Description Competition binding assay was used to measure the interaction between the phage-tagged kinase, immobilized competitive ligand, and unlinked test comp... | Proc Natl Acad Sci U S A 102: 11011-6 (2005) Article DOI: 10.1073/pnas.0504952102 BindingDB Entry DOI: 10.7270/Q29C6VNB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [201-500,H396P] (Homo sapiens (Human)) | BDBM13533 (1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a |
Ambit, Inc. | Assay Description Competition binding assay was used to measure the interaction between the phage-tagged kinase, immobilized competitive ligand, and unlinked test comp... | Proc Natl Acad Sci U S A 102: 11011-6 (2005) Article DOI: 10.1073/pnas.0504952102 BindingDB Entry DOI: 10.7270/Q29C6VNB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [201-500,T315I] (Homo sapiens (Human)) | BDBM13533 (1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a |
Ambit, Inc. | Assay Description Competition binding assay was used to measure the interaction between the phage-tagged kinase, immobilized competitive ligand, and unlinked test comp... | Proc Natl Acad Sci U S A 102: 11011-6 (2005) Article DOI: 10.1073/pnas.0504952102 BindingDB Entry DOI: 10.7270/Q29C6VNB | |||||||||||
More data for this Ligand-Target Pair |
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