Reaction Details |
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Target | Tyrosine-protein kinase ABL1 [201-500,Y253F] |
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Ligand | BDBM13216 |
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Substrate/Competitor | BDBM13531 |
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Meas. Tech. | Kinase Assay and Binding Constant Measurement |
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pH | 7.4±n/a |
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Temperature | 298.15±n/a K |
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Kd | 1±n/a nM |
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Citation | Carter, TA; Wodicka, LM; Shah, NP; Velasco, AM; Fabian, MA; Treiber, DK; Milanov, ZV; Atteridge, CE; Biggs, WH; Edeen, PT; Floyd, M; Ford, JM; Grotzfeld, RM; Herrgard, S; Insko, DE; Mehta, SA; Patel, HK; Pao, W; Sawyers, CL; Varmus, H; Zarrinkar, PP; Lockhart, DJ Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases. Proc Natl Acad Sci U S A102:11011-6 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Tyrosine-protein kinase ABL1 [201-500,Y253F] |
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Name: | Tyrosine-protein kinase ABL1 [201-500,Y253F] |
Synonyms: | ABL | ABL Mutant (Y253F) | ABL1 | ABL1_HUMAN | JTK7 | Proto-oncogene tyrosine-protein kinase ABL1 mutant Y253F | c-ABL | p150 |
Type: | Enzyme |
Mol. Mass.: | 34579.76 |
Organism: | Homo sapiens (Human) |
Description: | P00519[201-500,Y253F] |
Residue: | 300 |
Sequence: | HHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQFGEVYEGV
WKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTY
GNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVA
DFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPY
PGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQES
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BDBM13216 |
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BDBM13531 |
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Name | BDBM13216 |
Synonyms: | BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide | N-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide | US10294227, Code Dasatinib | US20230348453, Compound A8 | cid_3062316 | med.21724, Compound Dasatinib |
Type | Small organic molecule |
Emp. Form. | C22H26ClN7O2S |
Mol. Mass. | 488.006 |
SMILES | Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CCO)CC1 |
Structure |
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