Reaction Details |
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Target | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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Ligand | BDBM50359695 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_792217 (CHEMBL1930744) |
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IC50 | 27±n/a nM |
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Citation | Erra, M; Moreno, I; Sanahuja, J; Andrés, M; Reinoso, RF; Lozoya, E; Pizcueta, P; Godessart, N; Castro-Palomino, JC Biaryl analogues of teriflunomide as potent DHODH inhibitors. Bioorg Med Chem Lett21:7268-72 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Dihydroorotate dehydrogenase (quinone), mitochondrial |
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Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial |
Synonyms: | DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 42881.33 |
Organism: | Homo sapiens (Human) |
Description: | Q02127 |
Residue: | 395 |
Sequence: | MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVR
FTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSV
TPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVN
LGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQER
DGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTF
WGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
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BDBM50359695 |
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n/a |
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Name | BDBM50359695 |
Synonyms: | CHEMBL1929439 |
Type | Small organic molecule |
Emp. Form. | C21H17F3N2O5 |
Mol. Mass. | 434.3653 |
SMILES | CCC(=O)C(C#N)C(=O)Nc1ccc(-c2cccc(OC(F)(F)F)c2)c(c1)C(=O)OC |
Structure |
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