| Reaction Details |
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 | Report a problem with these data |
| Target | Stearoyl-CoA desaturase |
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| Ligand | BDBM50364041 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_805305 (CHEMBL1955198) |
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| IC50 | 969±n/a nM |
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| Citation |  Lachance, N; Guiral, S; Huang, Z; Leclerc, JP; Li, CS; Oballa, RM; Ramtohul, YK; Wang, H; Wu, J; Zhang, L Discovery of potent and liver-selective stearoyl-CoA desaturase (SCD) inhibitors in an acyclic linker series. Bioorg Med Chem Lett22:623-7 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Stearoyl-CoA desaturase |
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| Name: | Stearoyl-CoA desaturase |
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| Synonyms: | Acyl-CoA desaturase | FADS5 | SCD | SCD1 | SCDOS | SCD_HUMAN | Stearoyl-CoA (SCD1) | Stearoyl-CoA desaturase 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41537.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O00767 |
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| Residue: | 359 |
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| Sequence: | MPAHLLQDDISSSYTTTTTITAPPSRVLQNGGDKLETMPLYLEDDIRPDIKDDIYDPTYK
DKEGPSPKVEYVWRNIILMSLLHLGALYGITLIPTCKFYTWLWGVFYYFVSALGITAGAH
RLWSHRSYKARLPLRLFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFS
HVGWLLVRKHPAVKEKGSTLDLSDLEAEKLVMFQRRYYKPGLLMMCFILPTLVPWYFWGE
TFQNSVFVATFLRYAVVLNATWLVNSAAHLFGYRPYDKNISPRENILVSLGAVGEGFHNY
HHSFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAILARIKRTGDGNYKSG
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| BDBM50364041 |
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| n/a |
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| Name | BDBM50364041 |
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| Synonyms: | CHEMBL1950551 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H13BrF3N5O5S |
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| Mol. Mass. | 524.269 |
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| SMILES | OC(=O)Cn1nnc(n1)-c1cnc(OCCCOc2cc(OC(F)(F)F)ccc2Br)s1 |
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| Structure | 
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