Ki Summary

Reaction Details

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Target

S-adenosylmethionine decarboxylase proenzyme

Ligand

BDBM50281292

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_196574 (CHEMBL800452)

246600±n/a nM

Citation

Wu, YQ; Lawrence, T; Guo, JQ; Woster, PM -cyano-substituted analogoues of decarboxylated S-adenosylmethionine as enzyme activated, irreversible inhibitors of S-adenosylmethionine decarboxylase Bioorg Med Chem Lett3:2811-2816 (1993) Article

More Info.:

Get all data from this article, Assay Method

S-adenosylmethionine decarboxylase proenzyme

Name:

S-adenosylmethionine decarboxylase proenzyme

Synonyms:

Type:

Heterotetramer of two alpha and two beta chains

Mol. Mass.:

38337.21

Organism:

Homo sapiens (Human)

Description:

For the production of protein for the hAdoMetDC enzyme assays, the plasmid containing (H)6 tag at the carboxyl end (replacing -QQQQQS) was used.

Residue:

334

Sequence:

MEAAHFFEGTEKLLEVWFSRQQPDANQGSGDLRTIPRSEWDILLKDVQCSIISVTKTDKQ
EAYVLSESSMFVSKRRFILKTCGTTLLLKALVPLLKLARDYSGFDSIQSFFYSRKNFMKP
SHQGYPHRNFQEEIEFLNAIFPNGAAYCMGRMNSDCWYLYTLDFPESRVISQPDQTLEIL
MSELDPAVMDQFYMKDGVTAKDVTRESGIRDLIPGSVIDATMFNPCGYSMNGMKSDGTYW
TIHITPEPEFSYVSFETNLSQTSYDDLIRKVVEVFKPGKFVTTLFVNQSSKCRTVLASPQ
KIEGFKRLDCQSAMFNDYNFVFTSFAKKQQQQQS

BDBM50281292

n/a

Name

BDBM50281292

Synonyms:

2-amino-4-({[(2S,3S,4R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl}(methyl)-sulfanyl)butanenitrile dihydrobromide | CHEMBL3392189 | CHEMBL541928

Type

Small organic molecule

Emp. Form.

C15H23Br2N7O3S

Mol. Mass.

541.261

SMILES

Br.[Br-].C[S+](CCC(N)C#N)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12

Structure