| Reaction Details |
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 | Report a problem with these data |
| Target | S-adenosylmethionine decarboxylase proenzyme |
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| Ligand | BDBM50366316 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_197377 |
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| Ki | 960000±n/a nM |
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| Citation |  Guo, JQ; Wu, YQ; Farmer, WL; Douglas, KA; Woster, PM; Garofalo, J; Basshi, CJ Restricted rotation analogs of S-adenosylmethionine: synthesis, evaluation as inhibitors of S-adenosylmethionine decarboxylase, and potential use as selective antitrypanosomal agents Bioorg Med Chem Lett3:147-152 (1993) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| S-adenosylmethionine decarboxylase proenzyme |
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| Name: | S-adenosylmethionine decarboxylase proenzyme |
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| Synonyms: | AMD | AMD1 | DCAM_HUMAN | S-Adenosylmethionine Decarboxylase (AdoMetDC) | S-adenosylmethionine decarboxylase 1 | SAMDC |
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| Type: | Heterotetramer of two alpha and two beta chains |
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| Mol. Mass.: | 38337.21 |
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| Organism: | Homo sapiens (Human) |
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| Description: | For the production of protein for the hAdoMetDC enzyme assays, the plasmid containing (H)6 tag at the carboxyl end (replacing -QQQQQS) was used. |
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| Residue: | 334 |
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| Sequence: | MEAAHFFEGTEKLLEVWFSRQQPDANQGSGDLRTIPRSEWDILLKDVQCSIISVTKTDKQ
EAYVLSESSMFVSKRRFILKTCGTTLLLKALVPLLKLARDYSGFDSIQSFFYSRKNFMKP
SHQGYPHRNFQEEIEFLNAIFPNGAAYCMGRMNSDCWYLYTLDFPESRVISQPDQTLEIL
MSELDPAVMDQFYMKDGVTAKDVTRESGIRDLIPGSVIDATMFNPCGYSMNGMKSDGTYW
TIHITPEPEFSYVSFETNLSQTSYDDLIRKVVEVFKPGKFVTTLFVNQSSKCRTVLASPQ
KIEGFKRLDCQSAMFNDYNFVFTSFAKKQQQQQS
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| BDBM50366316 |
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| n/a |
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| Name | BDBM50366316 |
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| Synonyms: | CHEMBL3392209 | CHEMBL605267 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H22N6O9S2 |
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| Mol. Mass. | 494.5 |
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| SMILES | OS(O)(=O)=O.Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CS[C@H]2CN[C@@H](C2)C(O)=O)[C@@H](O)[C@H]1O |r| |
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| Structure | 
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