Reaction Details |
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Target | 5-hydroxytryptamine receptor 1A |
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Ligand | BDBM50011249 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_1534 |
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Ki | 2807±n/a nM |
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Citation | Mellin, C; Vallgårda, J; Nelson, DL; Björk, L; Yu, H; Andén, NE; Csöregh, I; Arvidsson, LE; Hacksell, U A 3-D model for 5-HT1A-receptor agonists based on stereoselective methyl-substituted and conformationally restricted analogues of 8-hydroxy-2-(dipropylamino)tetralin. J Med Chem34:497-510 (1991) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 1A |
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Name: | 5-hydroxytryptamine receptor 1A |
Synonyms: | 5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 46445.29 |
Organism: | Rattus norvegicus (rat) |
Description: | Binding assays were performed using rat hippocampal membranes. |
Residue: | 422 |
Sequence: | MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGT
SLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGN
SKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RR
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BDBM50011249 |
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n/a |
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Name | BDBM50011249 |
Synonyms: | 1-Propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[g]quinolin-9-ol; hydrochloride | CHEMBL541348 |
Type | Small organic molecule |
Emp. Form. | C16H23NO |
Mol. Mass. | 245.3599 |
SMILES | CCCN1CCC[C@@H]2Cc3cccc(O)c3C[C@@H]12 |
Structure |
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