| Reaction Details |
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 | Report a problem with these data |
| Target | Acyl-CoA:cholesterol acyltransferase |
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| Ligand | BDBM50005946 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_28339 |
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| IC50 | 410±n/a nM |
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| Citation |  Roth, BD; Blankley, CJ; Hoefle, ML; Holmes, A; Roark, WH; Trivedi, BK; Essenburg, AD; Kieft, KA; Krause, BR; Stanfield, RL Inhibitors of acyl-CoA:cholesterol acyltransferase. 1. Identification and structure-activity relationships of a novel series of fatty acid anilide hypocholesterolemic agents. J Med Chem35:1609-17 (1992) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Acyl-CoA:cholesterol acyltransferase |
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| Name: | Acyl-CoA:cholesterol acyltransferase |
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| Synonyms: | ACAT |
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| Type: | n/a |
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| Mol. Mass.: | 35405.31 |
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| Organism: | Oryctolagus cuniculus |
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| Description: | n/a |
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| Residue: | 305 |
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| Sequence: | PLFLKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSILKEMKNNHRAKDLRAPPEQGKIF
VARRSLLDELFEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFNLLSYAFGKLP
TVVWTWWTMFLSTLSIPYFLFQHWANGYSKSSHPLMYSLFHGLLFMVFQLGILGFGPTYI
VLAYTLPPASRFIVILEQIRLIMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLF
APTLIYRDSYPRTPTVRWGYVAMQFAQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVL
VLCIF
|
|
|
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| BDBM50005946 |
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| n/a |
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| Name | BDBM50005946 |
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| Synonyms: | 2,2-Dimethyl-dodecanoic acid (4-bromo-2,6-dimethyl-phenyl)-amide | CHEMBL297834 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H36BrNO |
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| Mol. Mass. | 410.431 |
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| SMILES | CCCCCCCCCCC(C)(C)C(=O)Nc1c(C)cc(Br)cc1C |
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| Structure | 
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