| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Polyunsaturated fatty acid 5-lipoxygenase |
|---|
| Ligand | BDBM50037050 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_177765 (CHEMBL785225) |
|---|
| IC50 | 7000±n/a nM |
|---|
| Citation |  Hibi, S; Okamoto, Y; Tagami, K; Numata, H; Kobayashi, N; Shinoda, M; Kawahara, T; Murakami, M; Oketani, K; Inoue, T Novel dual inhibitors of 5-lipoxygenase and thromboxane A2 synthetase: synthesis and structure-activity relationships of 3-pyridylmethyl-substituted 2-amino-6-hydroxybenzothiazole derivatives. J Med Chem37:3062-70 (1994) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Polyunsaturated fatty acid 5-lipoxygenase |
|---|
| Name: | Polyunsaturated fatty acid 5-lipoxygenase |
|---|
| Synonyms: | Alox5 | Arachidonate 5-lipoxygenase | LOX5_RAT |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 78082.31 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_1432947 |
|---|
| Residue: | 673 |
|---|
| Sequence: | MPSYTVTVATGSQWFAGTDDYIYLSLIGSAGCSEKHLLDKAFYNDFERGGRDSYDVTVDE
ELGEIYLVKIEKRKYRLHDDWYLKYITLKTPHDYIEFPCYRWITGEGEIVLRDGCAKLAR
DDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLN
YSKAMENLFINRFMHMFQSSWHDFADFEKIFVKISNTISERVKNHWQEDLMFGYQFLNGC
NPVLIKRCTELPKKLPVTTEMVECSLERQLSLEQEVQEGNIFIVDYELLDGIDANKTDPC
THQFLAAPICLLYKNLANKIVPIAIQLNQTPGEKNPIFLPTDSKYDWLLAKIWVRSSDFH
IHQTITHLLRTHLVSEVFGIAMYRQLPAVHPLFKLLVAHVRFTIAINTKAREQLNCEYGL
FDKANATGGGGHVQMVQRAVQDLTYSSLCFPEAIKARGMDNTEDIPYYFYRDDGLLVWEA
IQSFTTEVVSIYYEDDQVVEEDQELQDFVKDVYVYGMRGRKASGFPKSIKSREKLSEYLT
VVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWH
LGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMIRFRKNLEAIVSVIAERNKNKKLPYY
YLSPDRIPNSVAI
|
|
|
|---|
| BDBM50037050 |
|---|
| n/a |
|---|
| Name | BDBM50037050 |
|---|
| Synonyms: | 4-Phenyl-2-[(pyridin-3-ylmethyl)-amino]-benzothiazol-6-ol | CHEMBL322015 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H15N3OS |
|---|
| Mol. Mass. | 333.407 |
|---|
| SMILES | Oc1cc(-c2ccccc2)c2nc(NCc3cccnc3)sc2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
