Reaction Details |
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Target | Thromboxane-A synthase |
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Ligand | BDBM50037046 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_177767 (CHEMBL785227) |
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IC50 | 110±n/a nM |
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Citation | Hibi, S; Okamoto, Y; Tagami, K; Numata, H; Kobayashi, N; Shinoda, M; Kawahara, T; Murakami, M; Oketani, K; Inoue, T Novel dual inhibitors of 5-lipoxygenase and thromboxane A2 synthetase: synthesis and structure-activity relationships of 3-pyridylmethyl-substituted 2-amino-6-hydroxybenzothiazole derivatives. J Med Chem37:3062-70 (1994) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Thromboxane-A synthase |
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Name: | Thromboxane-A synthase |
Synonyms: | Cyp5 | Cyp5a1 | Cytochrome P450 5A1 | THAS_RAT | TXA synthase | TXS | Tbxas1 |
Type: | PROTEIN |
Mol. Mass.: | 59971.80 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_209768 |
Residue: | 533 |
Sequence: | MEVLGLLKFEVSGTVVTVTLSVVLLALLKWYSTSAFSRLRKLGIRHPEPSPFVGNLMFFR
QGFWESHLELRERYGPLCGYYLGRRMYIVISDPDMIKEVLVENFSNFSNRMASGLEPKLI
ADSVLMLRDRRWEEVRGALMSAFSPEKLNEMTPLISQACELLLSHLKHSAASGDAFDIQR
CYCCFTTNVVASVAFGIEVNSQDAPEDPFVQHCQRVFAFSTPRPLLALILSFPSIMVPLA
RILPNKNRDELNGFFNTLIRNVIALRDKQTAEERRGDFLQMVLDAQRSMSSVGVEAFDMV
TEALSSAECMGDPPQRCHPTSTAKPLTVDEIAGQAFLFLIAGHEITTNTLSFITYLLATH
PECQERLLKEVDLFMEKHPAPEYCNLQEGLPYLDMVVAETLRMYPPAFRFTREAAQDCEV
LGQHIPAGSVLEIAVGALHHDPEHWPNPETFDPERFTAEARLQQKPFTYLPFGAGPRSCL
GVRLGLLVVKLTLLQVLHKFRFEACPETQVPLQLESKSALCPKNGVYVKIVSR
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BDBM50037046 |
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n/a |
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Name | BDBM50037046 |
Synonyms: | 2-Amino-5-methoxy-7-methyl-4-pyridin-3-ylmethyl-benzothiazol-6-ol; dihydrochloride | CHEMBL543149 |
Type | Small organic molecule |
Emp. Form. | C15H15N3O2S |
Mol. Mass. | 301.364 |
SMILES | COc1c(O)c(C)c2sc(N)nc2c1Cc1cccnc1 |
Structure |
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