Ki Summary

Reaction Details

Report a problem with these data

Target

Muscarinic acetylcholine receptor M1

Ligand

BDBM50077559

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_138552 (CHEMBL746419)

EC50

4.9±n/a nM

Citation

Jeppesen, L; Olesen, PH; Hansen, L; Sheardown, MJ; Thomsen, C; Rasmussen, T; Jensen, AF; Christensen, MS; Rimvall, K; Ward, JS; Whitesitt, C; Calligaro, DO; Bymaster, FP; Delapp, NW; Felder, CC; Shannon, HE; Sauerberg, P 1-(1,2,5-Thiadiazol-4-yl)-4-azatricyclo[2.2.1.0(2,6)]heptanes as new potent muscarinic M1 agonists: structure-activity relationship for 3-aryl-2-propyn-1-yloxy and 3-aryl-2-propyn-1-ylthio derivatives. J Med Chem42:1999-2006 (1999) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Muscarinic acetylcholine receptor M1

Name:

Muscarinic acetylcholine receptor M1

Synonyms:

ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1

Type:

Protein

Mol. Mass.:

51442.54

Organism:

Homo sapiens (Human)

Description:

P11229

Residue:

460

Sequence:

MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVN
NYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLIS
FDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYI
QFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSS
SERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEV
VIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKE
KKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYAL
CNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC

BDBM50077559

n/a

Name

BDBM50077559

Synonyms:

1-{4-[3-(3-Fluoro-phenyl)-prop-2-ynyloxy]-[1,2,5]thiadiazol-3-yl}-4-aza-tricyclo[2.2.1.0*2,6*]heptane | CHEMBL304247

Type

Small organic molecule

Emp. Form.

C17H14FN3OS

Mol. Mass.

327.376

SMILES

n/a

Structure