Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Cholinesterase | ||
| Ligand | BDBM50094626 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_41591 (CHEMBL654885) | ||
| IC50 | 32.4±n/a nM | ||
| Citation |  Camps, P; El Achab R, na; Morral, J; Muñoz-Torrero, D; Badia, A; Baños, JE; Vivas, NM; Barril, X; Orozco, M; Luque, FJ New tacrine-huperzine A hybrids (huprines): highly potent tight-binding acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease. J Med Chem43:4657-66 (2001) [PubMed] | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Cholinesterase | |||
| Name: | Cholinesterase | ||
| Synonyms: | Acylcholine acylhydrolase | BCHE | Butyrylcholine esterase (BChE) | Butyrylcholinesterase (BChE) | Butyrylcholinesterase (BuChE) | CHE1 | CHLE_HUMAN | Choline esterase II | Cholinesterases | Cholinesterases; ACHE & BCHE | Pseudocholinesterase | ||
| Type: | Homotetramer | ||
| Mol. Mass.: | 68422.27 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P06276 | ||
| Residue: | 602 | ||
| Sequence: |
| ||
| BDBM50094626 | |||
| n/a | |||
| Name | BDBM50094626 | ||
| Synonyms: | (+)-15-ethyl-7-fluoro-10-azatetracyclo[11.3.1.02,11.04,9]heptadeca-2(11),3,5,7,9,14-hexaen-3-amine | (-)-15-ethyl-7-fluoro-10-azatetracyclo[11.3.1.02,11.04,9]heptadeca-2(11),3,5,7,9,14-hexaen-3-amine | 15-ethyl-7-fluoro-(1R,13S)-10-azoniatetracyclo[11.3.1.02,11.04,9]heptadeca-2,4,6,8,10,14-hexaen-3-amine | 15-ethyl-7-fluoro-10-azatetracyclo[11.3.1.02,11.04,9]heptadeca-2(11),3,5,7,9,14-hexaen-3-amine | CHEMBL341658 | rac-huprine H6 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C18H19FN2 | ||
| Mol. Mass. | 282.3553 | ||
| SMILES | CCC1=CC2CC(C1)c1c(C2)nc2cc(F)ccc2c1N |t:2,TLB:19:8:2.3.7:5| | ||
| Structure | 
| ||