| Reaction Details |
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 | Report a problem with these data |
| Target | Bile acid receptor |
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| Ligand | BDBM50117093 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_69698 (CHEMBL682033) |
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| EC50 | 1110±n/a nM |
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| Citation |  Pellicciari, R; Fiorucci, S; Camaioni, E; Clerici, C; Costantino, G; Maloney, PR; Morelli, A; Parks, DJ; Willson, TM 6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity. J Med Chem45:3569-72 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Bile acid receptor |
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| Name: | Bile acid receptor |
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| Synonyms: | BAR | Bile acid receptor FXR | FXR | Farnesol receptor HRR-1 | HRR1 | NR1H4 | NR1H4_HUMAN | Nuclear receptor subfamily 1 group H member 4 | RIP14 | RXR-interacting protein 14 | Retinoid X receptor-interacting protein 14 | farnesoid x receptor |
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| Type: | Nuclear Receptor |
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| Mol. Mass.: | 55916.24 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96RI1 |
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| Residue: | 486 |
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| Sequence: | MVMQFQGLENPIQISPHCSCTPSGFFMEMMSMKPAKGVLTEQVAGPLGQNLEVEPYSQYS
NVQFPQVQPQISSSSYYSNLGFYPQQPEEWYSPGIYELRRMPAETLYQGETEVAEMPVTK
KPRMGASAGRIKGDELCVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCV
MDMYMRRKCQECRLRKCKEMGMLAECMYTGLLTEIQCKSKRLRKNVKQHADQTVNEDSEG
RDLRQVTSTTKSCREKTELTPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLI
LTEMATNHVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPSGHSD
LLEERIRNSGISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDREAVEK
LQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELRTFNHHHAEMLMSWRVNDHKFTPLLC
EIWDVQ
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| BDBM50117093 |
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| n/a |
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| Name | BDBM50117093 |
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| Synonyms: | (R)-4-((3R,6R,7R,10S,13R)-3,7-Dihydroxy-10,13-dimethyl-6-propyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid | 4-(3,7-Dihydroxy-10,13-dimethyl-6-propyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid | CHEMBL292618 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H46O4 |
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| Mol. Mass. | 434.6517 |
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| SMILES | CCC[C@H]1[C@@H](O)C2C3CCC([C@H](C)CCC(O)=O)[C@@]3(C)CCC2[C@@]2(C)CC[C@@H](O)CC12 |
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| Structure | 
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