Ki Summary

Reaction Details

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Target

Tyrosine-protein phosphatase non-receptor type 1

Ligand

BDBM50185127

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_358378 (CHEMBL854300)

IC50

>100000±n/a nM

Citation

Na, M; Cui, L; Min, BS; Bae, K; Yoo, JK; Kim, BY; Oh, WK; Ahn, JS Protein tyrosine phosphatase 1B inhibitory activity of triterpenes isolated from Astilbe koreana. Bioorg Med Chem Lett16:3273-6 (2006) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Tyrosine-protein phosphatase non-receptor type 1

Name:

Tyrosine-protein phosphatase non-receptor type 1

Synonyms:

Type:

Protein phosphatase

Mol. Mass.:

49963.76

Organism:

Homo sapiens (Human)

Description:

Human recombinant GST-fusion PTP1B (1-435).

Residue:

435

Sequence:

MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH
QEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLK
CAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWP
DFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKD
PSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLE
PPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYG
IESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLT
AGAYLCYRFLFNSNT

BDBM50185127

n/a

Name

BDBM50185127

Synonyms:

(3beta,20beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl-2-O-beta-D-glucopyranuronosyl-alpha-D-glucopyranosiduronic acid | 30-hydroxy-11,30-dioxoolean-12-en-3beta-yl (2-O-beta-D-glucopyranosyluronic acid)-alpha-D-glucopyranosiduronic acid | CHEMBL441687 | glycyrrhizic acid | glycyrrhizinic acid | glyzyrrhizin

Type

Small organic molecule

Emp. Form.

C42H62O16

Mol. Mass.

822.9321

SMILES

CC1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O)O[C@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O[C@@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)C(O)=O)C(O)=O |r,t:18|

Structure